塞马鲁肽与 2 型糖尿病患者的戒烟:无烟不成火!

IF 3.6 3区 医学 Q2 PHARMACOLOGY & PHARMACY Expert Review of Clinical Pharmacology Pub Date : 2024-10-21 DOI:10.1080/17512433.2024.2418398
Djordje S Popovic, Dimitrios Patoulias, Theocharis Koufakis, Paschalis Karakasis, Ieva Ruža, Nikolaos Papanas
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引用次数: 0

摘要

吸烟是导致全球过早死亡的主要可预防风险因素。一项对 74 项流行病学研究(包括来自 33 个国家的 320 万 2 型糖尿病(T2DM)患者)的荟萃分析报告显示,T2DM 患者的吸烟率为 20.8%。吸烟进一步加剧了 T2DM 对血管的有害影响。也就是说,慢性高血糖和暴露于香烟烟雾会对血管内皮产生叠加伤害效应,从而加速 T2DM 和烟草使用障碍(TUD)患者的血管并发症。在最近的一项研究中,Wang 及其同事发现,与其他抗糖尿病药物相比,使用塞马鲁肽可显著降低因 TUD 而就医的风险;事实上,与胰岛素相比,这种效应最强,而与其他胰高血糖素样肽-1 受体激动剂相比,这种效应最弱。塞马鲁肽与戒烟药物处方和咨询的减少有关。无论是否存在肥胖,都观察到了类似的结果。因此,使用塞马鲁肽可能有助于T2DM患者戒烟,从而为这一不断增长的人群带来额外的益处。不过,这些有趣的发现还需要通过专门的大规模随机对照试验来证实。
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Semaglutide and smoking cessation in individuals with type 2 diabetes mellitus: there is no smoke without fire!

Tobacco use represents the leading preventable risk factor for premature deaths worldwide. A meta-analysis of 74 epidemiological studies, including 3.2 million individuals with type 2 diabetes mellitus (T2DM) from 33 countries, reported a pooled prevalence of smoking of 20.8% among individuals with T2DM. Cigarette smoking further aggravates existing deleterious vascular effects of T2DM. Namely, chronic hyperglycemia and exposure to cigarette smoke cause additive injurious effect on the endothelium, leading to an acceleration of vascular complications seen in persons with T2DM and tobacco use disorders (TUD). In a recent study, Wang and colleagues found that semaglutide use was associated with a significantly lower risk for medical encounters for TUD, when compared to other antidiabetic drug classes; indeed, this effect was strongest compared with insulins and weakest compared with other glucagon-like peptide-1 receptor agonists. Semaglutide was associated with reduced smoking cessation medication prescriptions and counseling. Similar findings were observed irrespective of the presence of obesity. Therefore, semaglutide use might be useful in terms of smoking cessation among individuals with T2DM, thus offering an additional benefit for this constantly growing population. However, those interesting findings should be confirmed through dedicated, large-scale randomized controlled trials.

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来源期刊
Expert Review of Clinical Pharmacology
Expert Review of Clinical Pharmacology PHARMACOLOGY & PHARMACY-
CiteScore
7.30
自引率
2.30%
发文量
127
期刊介绍: Advances in drug development technologies are yielding innovative new therapies, from potentially lifesaving medicines to lifestyle products. In recent years, however, the cost of developing new drugs has soared, and concerns over drug resistance and pharmacoeconomics have come to the fore. Adverse reactions experienced at the clinical trial level serve as a constant reminder of the importance of rigorous safety and toxicity testing. Furthermore the advent of pharmacogenomics and ‘individualized’ approaches to therapy will demand a fresh approach to drug evaluation and healthcare delivery. Clinical Pharmacology provides an essential role in integrating the expertise of all of the specialists and players who are active in meeting such challenges in modern biomedical practice.
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