使用丁吗啡诺作为局部麻醉剂,为接受脐疝修补术的犊牛止痛。

IF 2.6 2区 农林科学 Q1 VETERINARY SCIENCES Frontiers in Veterinary Science Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI:10.3389/fvets.2024.1470957
Claudia Interlandi, Filippo Spadola, Veronica C Neve, Marco Tabbì, Simona Di Pietro, Elisabetta Giudice, Daniele Macrì, Giovanna L Costa
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引用次数: 0

摘要

这项研究的目的是比较丁吗啡醇和利多卡因单独或混合使用对接受脐疝手术修复的犊牛的镇痛效果。研究对象是 60 头不同品种的小牛。研究中的所有动物均肌肉注射了 0.3 毫克/千克的赛拉嗪。然后将动物分为三组(n = 20),分别接受利多卡因 4.5 毫克/千克和丁吗啡醇 0.02 毫克/千克的不同治疗。L 组接受利多卡因手术平面浸润和腹腔注射,B 组接受丁吗啡醇手术平面浸润和腹腔注射,最后 LB 组接受利多卡因手术平面浸润和丁吗啡醇腹腔注射。手术期间记录心率和呼吸频率、血红蛋白氧饱和度、无创血压和体温。对手术刺激的反应按累积数字表进行评分,其中包括心率、呼吸频率和 SAP 的百分比变化。术后疼痛由三名独立观察者进行评估,他们对治疗过程视而不见,使用的是用于评估牛术后疼痛的 UNESP-Botucatu 单维综合疼痛量表(UNESP-Botucatu UCPS-IV)。生理变量的变化过程符合麻醉患者的情况。没有受试者需要术中镇痛抢救。在 L 组中,40 米处有 4 名受试者,50 米处有 5 名受试者需要术后镇痛抢救。无论是单用丁吗啡诺还是丁吗啡诺和利多卡因的组合,术中和术后评分都非常出色。此外,这种组合没有引起任何心肺或其他不良反应。根据这项研究的结果,无论是单独使用丁吗啡醇,还是在局部同时使用丁吗啡醇和利多卡因,都能安全有效地为犊牛提供充分而持久的镇痛,有助于减轻术后不适感,并维持适当的动物福利。
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Use of butorphanol as a local anaesthetic for pain management in calves undergoing umbilical hernia repair.

The aim of the study was to compare the analgesic efficacy of butorphanol and lidocaine, alone or in combination, in calves undergoing surgical repair of umbilical hernia. The study was conducted in 60 calves of different breeds. Xylazine 0.3 mg/kg was administered intramuscularly to all animals in the study. The animals were then divided into three groups (n = 20) that received different treatments with lidocaine at 4.5 mg/kg and butorphanol at 0.02 mg/kg. The L group received lidocaine both by infiltration of the surgical planes and intraperitoneally, the B group received butorphanol both by infiltration of the surgical planes and intraperitoneally, and finally the LB group received lidocaine by infiltration of the surgical planes and butorphanol intraperitoneally. Heart and respiratory rates, haemoglobin oxygen saturation, non-invasive blood pressure and temperature were recorded during surgery. Response to the surgical stimulus was scored on a cumulative numerical scale that included percentage changes in HR, RR and SAP. Postoperative pain was assessed by three independent observers, blinded to treatment, using the UNESP-Botucatu Unidimensional Composite Pain Scale (UNESP-Botucatu UCPS-IV) for the assessment of postoperative pain in cattle. The course of physiological variables was appropriate for patients under anaesthesia. No subject required rescue intraoperative analgesia. In group L, 4 subjects at 40 m and 5 subjects at 50 m required postoperative rescue analgesia. Both butorphanol alone and the combination of butorphanol and lidocaine showed excellent intraoperative and postoperative scores. Furthermore, this combination did not cause any cardiopulmonary or other adverse effects. Based on the results of this study, both butorphanol alone and the co-administration of butorphanol and lidocaine administered locally proved to be safe and effective in providing adequate and long-lasting analgesia in calves, helping to reduce postoperative discomfort and maintaining adequate animal welfare.

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来源期刊
Frontiers in Veterinary Science
Frontiers in Veterinary Science Veterinary-General Veterinary
CiteScore
4.80
自引率
9.40%
发文量
1870
审稿时长
14 weeks
期刊介绍: Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy. Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field. Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.
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