Sophia Duenas, Zachary McGee, Ishani Mhatre, Karthikeyan Mayilvahanan, Kush Ketan Patel, Habiba Abdelhalim, Atharv Jayprakash, Uzayr Wasif, Oluchi Nwankwo, William Degroat, Naveena Yanamala, Partho P Sengupta, Daniel Fine, Zeeshan Ahmed
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引用次数: 0
摘要
牙周炎是一种高发的炎症性疾病,会导致牙齿支撑组织结构的破坏,并与心血管疾病(CVD)风险的增加有关。精准医疗是医疗领域的一个新兴分支,其目的是根据个人的环境、基因构成和生活方式进行个性化治疗,从而进一步改善目前的传统治疗方法。基因组数据库阐明了复杂的遗传性疾病的病理生理学,为精准医疗铺平了道路。因此,研究与心血管疾病相关的新型牙周炎关联基因将加深我们对其关联性和相关生化途径的了解,从而为靶向治疗提供依据。在本文中,我们将强调牙周病和心血管疾病之间可能的作用机制。此外,我们还将深入探讨将二者联系起来的某些遗传性炎症相关途径。我们的目标是收集、比较和评估高质量的科学文献以及基因组数据集,以寻求建立牙周炎与心血管疾病之间的联系。研究范围主要集中在过去 10 年内发表的、被 PubMed Central 索引并提供的、分析与心血管疾病相关的牙周炎相关基因的最新真实文献。根据比较分析标准,确定并报告了 51 个与牙周炎和心血管疾病相关的基因。心血管疾病和牙周炎相关基因的普遍性值得研究,以评估这两种疾病的病理生理学之间潜在联系的有效性。
Computational approaches to investigate the relationship between periodontitis and cardiovascular diseases for precision medicine.
Periodontitis is a highly prevalent inflammatory illness that leads to the destruction of tooth supporting tissue structures and has been associated with an increased risk of cardiovascular disease (CVD). Precision medicine, an emerging branch of medical treatment, aims can further improve current traditional treatment by personalizing care based on one's environment, genetic makeup, and lifestyle. Genomic databases have paved the way for precision medicine by elucidating the pathophysiology of complex, heritable diseases. Therefore, the investigation of novel periodontitis-linked genes associated with CVD will enhance our understanding of their linkage and related biochemical pathways for targeted therapies. In this article, we highlight possible mechanisms of actions connecting PD and CVD. Furthermore, we delve deeper into certain heritable inflammatory-associated pathways linking the two. The goal is to gather, compare, and assess high-quality scientific literature alongside genomic datasets that seek to establish a link between periodontitis and CVD. The scope is focused on the most up to date and authentic literature published within the last 10 years, indexed and available from PubMed Central, that analyzes periodontitis-associated genes linked to CVD. Based on the comparative analysis criteria, fifty-one genes associated with both periodontitis and CVD were identified and reported. The prevalence of genes associated with both CVD and periodontitis warrants investigation to assess the validity of a potential linkage between the pathophysiology of both diseases.
期刊介绍:
Human Genomics is a peer-reviewed, open access, online journal that focuses on the application of genomic analysis in all aspects of human health and disease, as well as genomic analysis of drug efficacy and safety, and comparative genomics.
Topics covered by the journal include, but are not limited to: pharmacogenomics, genome-wide association studies, genome-wide sequencing, exome sequencing, next-generation deep-sequencing, functional genomics, epigenomics, translational genomics, expression profiling, proteomics, bioinformatics, animal models, statistical genetics, genetic epidemiology, human population genetics and comparative genomics.