对肿瘤和邻近非肿瘤蛋白质组数据的综合分析表明,SERPINH1 是肝细胞癌的复发生物标志物和药物靶点。

IF 8.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY International Journal of Biological Sciences Pub Date : 2024-09-23 eCollection Date: 2024-01-01 DOI:10.7150/ijbs.99734
Yushan Hou, Yiming Zhang, Kun Zheng, Han Wang, Yingying Zhou, Yuanjun Zhai, Fuchu He, Chunyan Tian, Aihua Sun
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引用次数: 0

摘要

肝细胞癌(HCC)术后复发率高,导致预后不佳,目前尚缺乏有效的复发管理策略。本研究基于五种癌症类型的七对肿瘤和非肿瘤邻近组织(NATs)蛋白质组数据集,系统研究了肿瘤和NATs对肿瘤复发的分层和治疗价值。NATs对复发具有稳定且不可替代的独立预后能力,是对临床指标和肿瘤特征的补充。与肿瘤组织相比,NATs在免疫、细胞外基质和血管生成等通路中显示出更高的复发相关蛋白富集水平。以 HCC 为例,我们发现 SERPINH1 是一种具有药物靶向潜力的复发生物标记物,同时适用于肿瘤和 NATs,并通过独立的免疫组化队列和动物实验进行了验证。SERPINH1在肿瘤和NAT中均有高表达的患者5年复发率最高,即使在临床上复发风险较低的群体中也是如此。以 SERPINH1 为靶点可有效延缓肿瘤的发生和发展。本研究强调了NATs在复发预测和术后管理中的重要作用,提出了一种同时关注肿瘤和NATs的复发管理策略。SERPINH1 成为解决 HCC 术后复发问题的重要生物标记物和药物靶点。
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Integrated analysis of tumor and adjacent non-tumor proteomic data reveals SERPINH1 as a recurrence biomarker and drug target in hepatocellular carcinoma.

The high rate of postoperative recurrence contributes to the poor outcome in hepatocellular carcinoma (HCC), and effective strategies for managing recurrence are currently lacking. Based on seven pairs of tumors and non-tumor adjacent tissues (NATs) proteomic datasets across five cancer types, this study systematically investigates the stratified and therapeutic value of tumors and NATs for tumor recurrence. NATs exhibited stable and irreplaceable independent prognostic capabilities for recurrence, complementing clinical indicators and tumor characteristics. In comparison to tumor tissues, NATs exhibit higher enrichment levels of recurrence-related proteins in pathways such as immunity, extracellular matrix, and angiogenesis. Taking HCC as an example, we identified SERPINH1 as a recurrent biomarker with drug-targeting potential that applied to both tumors and NATs and then validated them through independent immunohistochemistry cohorts and animal experiments. Patients with high SERPINH1 expression in both tumors and NATs have the highest 5-year recurrence rates, even among clinically low recurrence risk groups. Targeting SERPINH1 can effectively delay tumor occurrence and progression. This study highlights the significant importance of NATs in recurrence prediction and postoperative management, proposing a recurrence management strategy that focuses on both tumors and NATs. SERPINH1 emerges as a valuable biomarker and drug target for addressing postoperative recurrence in HCC.

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来源期刊
International Journal of Biological Sciences
International Journal of Biological Sciences 生物-生化与分子生物学
CiteScore
16.90
自引率
1.10%
发文量
413
审稿时长
1 months
期刊介绍: The International Journal of Biological Sciences is a peer-reviewed, open-access scientific journal published by Ivyspring International Publisher. It dedicates itself to publishing original articles, reviews, and short research communications across all domains of biological sciences.
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