Hui Peng, Qian Jiang, Wenhao Mao, Zhonglan Hu, Qi Wang, Zhuo Yu, Li Zhang, Xinyan Wang, Chunbo Zhuang, Jia Mai, Zhiyuan Wang, Ting Sun
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Moreover, the iron nanoparticles on Fe-HCOF-PEG<sup>2000</sup> caused ferroptosis and further enhanced tumor elimination under normoxic and hypoxic conditions. DSPE-PEG<sup>2000</sup> endowed Fe-HCOF-PEG<sup>2000</sup> with hydrophilicity, allowing it to circulate and accumulate in organs rich in blood supply, especially tumors. 808 nm NIR activated Fe-HCOF-PEG<sup>2000</sup> aggregated in tumors and significantly inhibited tumor growth under hypoxia.</p><p><strong>Conclusion: </strong>To our knowledge, Fe-HCOF-PEG<sup>2000</sup> is the leading combination of type I/II PDT and ferroptosis. The strong antitumor effects of this nanomaterial suggest prospects for clinical translation as a tumor nanotherapy drug.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"19 ","pages":"10165-10183"},"PeriodicalIF":6.6000,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11468433/pdf/","citationCount":"0","resultStr":"{\"title\":\"Fe-HCOF-PEG<sup>2000</sup> as a Hypoxia-Tolerant Photosensitizer to Trigger Ferroptosis and Enhance ROS-Based Cancer Therapy.\",\"authors\":\"Hui Peng, Qian Jiang, Wenhao Mao, Zhonglan Hu, Qi Wang, Zhuo Yu, Li Zhang, Xinyan Wang, Chunbo Zhuang, Jia Mai, Zhiyuan Wang, Ting Sun\",\"doi\":\"10.2147/IJN.S479848\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The hypoxic tumor microenvironment and single mechanisms severely limit the photodynamic therapy (PDT) efficiency of covalent organic framework (COF) nanoparticles in cancer treatment.</p><p><strong>Purpose: </strong>Here, we propose an iron-loaded, hydrophilic 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG2000)-modified hollow covalent organic framework (HCOF), Fe-HCOF-PEG<sup>2000</sup>, for use in hypoxic PDT and ferroptosis therapy owing to its type I and II photodynamic ability and iron nanoparticle loading property.</p><p><strong>Results: </strong>Fe-HCOF-PEG<sup>2000</sup> nanoparticles (Fe-HCOFs-PEG<sup>2000</sup>) with semiconducting polymers and microporous skeletons allow efficient photophysical properties. 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Fe-HCOF-PEG2000 as a Hypoxia-Tolerant Photosensitizer to Trigger Ferroptosis and Enhance ROS-Based Cancer Therapy.
Background: The hypoxic tumor microenvironment and single mechanisms severely limit the photodynamic therapy (PDT) efficiency of covalent organic framework (COF) nanoparticles in cancer treatment.
Purpose: Here, we propose an iron-loaded, hydrophilic 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG2000)-modified hollow covalent organic framework (HCOF), Fe-HCOF-PEG2000, for use in hypoxic PDT and ferroptosis therapy owing to its type I and II photodynamic ability and iron nanoparticle loading property.
Results: Fe-HCOF-PEG2000 nanoparticles (Fe-HCOFs-PEG2000) with semiconducting polymers and microporous skeletons allow efficient photophysical properties. Moreover, the iron nanoparticles on Fe-HCOF-PEG2000 caused ferroptosis and further enhanced tumor elimination under normoxic and hypoxic conditions. DSPE-PEG2000 endowed Fe-HCOF-PEG2000 with hydrophilicity, allowing it to circulate and accumulate in organs rich in blood supply, especially tumors. 808 nm NIR activated Fe-HCOF-PEG2000 aggregated in tumors and significantly inhibited tumor growth under hypoxia.
Conclusion: To our knowledge, Fe-HCOF-PEG2000 is the leading combination of type I/II PDT and ferroptosis. The strong antitumor effects of this nanomaterial suggest prospects for clinical translation as a tumor nanotherapy drug.
期刊介绍：
The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area.
With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field.
Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.
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