在成熟恒牙中使用粉碎的牙髓组织移植进行牙髓再生手术:临床研究。

IF 3.5 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Journal of endodontics Pub Date : 2024-10-12 DOI:10.1016/j.joen.2024.10.004
Ukseong Kim, Sunil Kim, Stephanie Myeong Choi, Mo K Kang, Insoon Chang, Euiseong Kim
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引用次数: 0

摘要

简介:使用基于细胞的方法进行牙髓再生治疗(REPs)已成为一种新的治疗模式。本临床研究旨在介绍在成熟牙中使用碎牙髓组织(MP)移植进行牙髓再生治疗的结果,并探讨影响其结果的因素:本研究选取了六名需要进行非手术根管治疗的 20-27 岁健康男性患者。将从第三磨牙上获取的骨髓组织引入经过器械处理、消毒和充血的根管中。用生物陶瓷水门汀封闭根管,并修复冠状通路腔:六个病例的随访时间从 19 个月到 42 个月不等。所有牙齿的影像学结果均良好。在这六颗牙齿中,有两颗既没有出现牙槽骨内钙化,也没有在敏感性测试中得到恢复,有一颗没有出现牙槽骨内钙化,但敏感性测试评估不适用。有两颗牙齿的根尖三分之一处出现牙槽骨内钙化,但在感度测试中没有恢复。有一颗牙齿的根尖三分之一处出现了牙槽骨内钙化,但在感度测试中显示已经恢复。考虑到这些结果和临床变量,根尖孔的大小和移植牙髓组织的成分被确定为初步的影响因素:这项关于使用自体 MP 进行成人牙髓/牙本质再生的简化细胞疗法的研究不仅加深了我们对 REPs 的理解,还表明它有可能成为传统牙髓治疗的替代治疗方案。
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Regenerative Endodontic Procedures With Minced Pulp Tissue Graft in Mature Permanent Teeth: A Clinical Study.

Introduction: Regenerative endodontic procedures (REPs) using cell-based approaches have emerged as novel treatment modalities. This clinical study aimed to present the outcomes and explore factors influencing REPs with minced pulp tissue (MP) grafts in a mature tooth.

Methods: Healthy patients requiring non-surgical root canal treatment were enrolled. MP obtained from the third molar was grafted into the instrumented, disinfected, and blood-filled root canal. After treatment, patients were evaluated clinically and radiographically.

Results: Follow-ups for 6 cases (male patients aged 20-27) ranged from 19 to 42 months. Radiographically, all the teeth showed favorable outcomes. Among the 6 teeth, 2 showed neither intracanal calcification nor recovery in sensibility tests, and one had no intracanal calcification with an inapplicable sensibility test evaluation. In 2 teeth, intracanal calcification was observed in the apical third; however, there was no recovery in the sensibility tests. One tooth exhibited intracanal calcification in the apical third and showed recovery in the sensibility tests. Considering these outcomes and clinical variables, the size of the apical foramen and the composition of the transplanted pulp tissue were identified as tentative influencing factors.

Conclusions: This exploratory clinical study on simplified cell-based REPs using autologous MP grafts for pulp/dentin regeneration in adult teeth not only enhances our understanding of REPs but also suggests its potential as an alternative treatment option to conventional endodontic treatment.

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来源期刊
Journal of endodontics
Journal of endodontics 医学-牙科与口腔外科
CiteScore
8.80
自引率
9.50%
发文量
224
审稿时长
42 days
期刊介绍: The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment. Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in techniques and instrumentation in the one journal that helps them keep pace with rapid changes in this field.
期刊最新文献
A methodological study on microbial in vivo sampling methods of root canal microbiota for next generation gene sequencing analysis. Exploring relationships between circulating interleukins and pulp and periapical diseases: a bidirectional Mendelian Randomization study. Leukemia and lymphoma mimicking periapical conditions resulting in endodontic treatment: a systematic review. Peripheral Lysosomal Positioning in Inflamed Odontoblasts Facilitates Mineralization. Corrigendum.
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