使用剂量递增法成功施用西妥昔单抗：病例报告。

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL Journal of Medical Case Reports Pub Date : 2024-10-17 DOI:10.1186/s13256-024-04815-6

Shasha Li, Yanjuan Zhang, Jiandong Zha, Wenqi Chen

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引用次数: 0

摘要

简介：西妥昔单抗用于治疗头颈部鳞癌和转移性结直肠癌，可引起严重的输液反应：西妥昔单抗用于治疗头颈部鳞状细胞癌和转移性结直肠癌，可引起严重的输液反应：我们报告了一名 87 岁的东亚妇女，她患有回盲部标志环细胞癌 IV 期，尽管预先接受了西妥昔单抗治疗，但仍出现了严重的过敏反应。我们采用了剂量递增法，即每周递增剂量，同时进行全面预处理和密切监测，成功减少了过敏反应，实现了安全用药：这种方法为对西妥昔单抗过敏的患者提供了一种可行的选择，值得进一步研究，以优化个性化治疗。

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Successful administration of cetuximab using dose escalation method: a case report.

Introduction: Cetuximab, used to treat head and neck squamous cell carcinoma and metastatic colorectal cancer, can cause severe infusion reactions.

Case presentation: We report an 87-year-old East Asian woman with stage IV ileocecal signet ring cell carcinoma who experienced severe allergic reactions to cetuximab despite pre-treatment. A dose escalation method, involving weekly incremental doses with comprehensive pre-treatment and close monitoring, was employed, successfully reducing allergic reactions and allowing safe administration.

Conclusion: This approach demonstrates a viable alternative for patients with hypersensitivity to cetuximab, warranting further research for personalized treatment optimization.

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来源期刊

Journal of Medical Case Reports Medicine-Medicine (all)

CiteScore

1.50

自引率

0.00%

发文量

436

期刊介绍： JMCR is an open access, peer-reviewed online journal that will consider any original case report that expands the field of general medical knowledge. Reports should show one of the following: 1. Unreported or unusual side effects or adverse interactions involving medications 2. Unexpected or unusual presentations of a disease 3. New associations or variations in disease processes 4. Presentations, diagnoses and/or management of new and emerging diseases 5. An unexpected association between diseases or symptoms 6. An unexpected event in the course of observing or treating a patient 7. Findings that shed new light on the possible pathogenesis of a disease or an adverse effect