基于人工智能的肝硬化预后评估。

IF 5.3 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY ACS Applied Nano Materials Pub Date : 2024-10-14 DOI:10.1186/s12967-024-05726-2
Yinping Zhai, Darong Hai, Li Zeng, Chenyan Lin, Xinru Tan, Zefei Mo, Qijia Tao, Wenhui Li, Xiaowei Xu, Qi Zhao, Jianwei Shuai, Jingye Pan
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引用次数: 0

摘要

肝硬化是一项重大的全球性健康挑战,其发病率和死亡率都很高,严重影响人类健康。及时、准确的肝硬化预后评估对改善患者预后和降低死亡率至关重要,因为它能让医生识别高危患者并实施早期干预。本文对肝硬化预后评估进行了全面的文献综述,旨在总结和描述传统预后评估工具在临床应用中的现状和制约因素。在这些工具中,主要使用 Child-Pugh 和终末期肝病模型 (MELD) 评分系统。然而,它们的准确性差异很大。这些系统通常适用于广泛的评估,但缺乏针对具体病情的适用性,也无法捕捉与患者病情动态变化相关的风险。该领域的未来研究将深入探索人工智能(AI)与肝硬化患者常规临床和多组学数据的整合。目标是从静态、单模态评估模型过渡到动态、多模态框架。这种进步不仅能提高预后工具的精确度,还能促进个性化医疗方法的发展,从而有可能彻底改变临床结果。
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Artificial intelligence-based evaluation of prognosis in cirrhosis.

Cirrhosis represents a significant global health challenge, characterized by high morbidity and mortality rates that severely impact human health. Timely and precise prognostic assessments of liver cirrhosis are crucial for improving patient outcomes and reducing mortality rates as they enable physicians to identify high-risk patients and implement early interventions. This paper features a thorough literature review on the prognostic assessment of liver cirrhosis, aiming to summarize and delineate the present status and constraints associated with the application of traditional prognostic tools in clinical settings. Among these tools, the Child-Pugh and Model for End-Stage Liver Disease (MELD) scoring systems are predominantly utilized. However, their accuracy varies significantly. These systems are generally suitable for broad assessments but lack condition-specific applicability and fail to capture the risks associated with dynamic changes in patient conditions. Future research in this field is poised for deep exploration into the integration of artificial intelligence (AI) with routine clinical and multi-omics data in patients with cirrhosis. The goal is to transition from static, unimodal assessment models to dynamic, multimodal frameworks. Such advancements will not only improve the precision of prognostic tools but also facilitate personalized medicine approaches, potentially revolutionizing clinical outcomes.

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来源期刊
CiteScore
8.30
自引率
3.40%
发文量
1601
期刊介绍: ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.
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