腹膜间皮瘤的系统治疗方案。

IF 14.8 2区 医学 Q1 ONCOLOGY Journal of the National Comprehensive Cancer Network Pub Date : 2024-10-01 DOI:10.6004/jnccn.2024.7031
Tawee Tanvetyanon, George R Simon
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引用次数: 0

摘要

腹膜间皮瘤是一种不常见的恶性肿瘤,美国每年新增约 300 名患者。由于发病率低,专门针对这种疾病的前瞻性临床试验很少。有关全身治疗的建议大多是从胸膜间皮瘤患者的临床试验中推断出来的。目前,推荐的一线系统治疗方案可包括尼伐单抗加伊匹单抗的免疫疗法,或培美曲塞加顺铂或卡铂的化疗。在二线治疗中,可以使用之前未选择的其他一线治疗方案。对于经过严格筛选的患者,可考虑在标示外使用贝伐单抗与化疗联合治疗。三线或三线以上治疗的益处尚不明确。然而,一些单药治疗方案显示出适度的活性。一些关于儿童或年轻成人腹膜间皮瘤患者携带 ALK 重排的轶事报道表明,ALK 抑制剂对这一罕见人群具有疗效。总之,腹膜间皮瘤的系统治疗选择越来越多。为了更好地了解这种疾病,未来的间皮瘤前瞻性试验应包括更多的腹膜间皮瘤患者。
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Systemic Therapy Options for Peritoneal Mesothelioma.

Peritoneal mesothelioma is an uncommon malignancy affecting approximately 300 new patients annually in the United States. Due to its low incidence, prospective clinical trials specific to this disease are scant. Recommendations regarding systemic therapy are mostly extrapolated from clinical trials conducted among patients with pleural mesothelioma. At present, the recommended first-line systemic treatment options may include immunotherapy with nivolumab plus ipilimumab or chemotherapy with pemetrexed plus either cisplatin or carboplatin. For second-line treatment, the other previously unchosen first-line option can be used. Off-label bevacizumab may be considered in combination with chemotherapy among carefully selected patients. The benefit of third-line treatment or beyond is less clear. Nonetheless, a number of single-agent regimens show modest activity. Anecdotal reports of children or young adults with peritoneal mesothelioma harboring ALK rearrangement have suggested the efficacy of ALK inhibitors for this rare population. In summary, there is a growing number of systemic therapy options for peritoneal mesothelioma. To gain a better insight into this disease, future prospective trials in mesothelioma should include more patients with peritoneal mesothelioma.

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来源期刊
CiteScore
20.20
自引率
0.00%
发文量
388
审稿时长
4-8 weeks
期刊介绍: JNCCN—Journal of the National Comprehensive Cancer Network is a peer-reviewed medical journal read by over 25,000 oncologists and cancer care professionals nationwide. This indexed publication delivers the latest insights into best clinical practices, oncology health services research, and translational medicine. Notably, JNCCN provides updates on the NCCN Clinical Practice Guidelines in Oncology® (NCCN Guidelines®), review articles elaborating on guideline recommendations, health services research, and case reports that spotlight molecular insights in patient care. Guided by its vision, JNCCN seeks to advance the mission of NCCN by serving as the primary resource for information on NCCN Guidelines®, innovation in translational medicine, and scientific studies related to oncology health services research. This encompasses quality care and value, bioethics, comparative and cost effectiveness, public policy, and interventional research on supportive care and survivorship. JNCCN boasts indexing by prominent databases such as MEDLINE/PubMed, Chemical Abstracts, Embase, EmCare, and Scopus, reinforcing its standing as a reputable source for comprehensive information in the field of oncology.
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