LncRNA NRIR 是系统性红斑狼疮的生物标志物,并参与疾病的进展。

IF 1.9 4区 医学 Q3 RHEUMATOLOGY Lupus Pub Date : 2024-10-20 DOI:10.1177/09612033241294032
Qingfeng Ma, Li Li, Youzhong Xing
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引用次数: 0

摘要

背景:系统性红斑狼疮(SLE)是一种复杂的自身免疫性疾病:系统性红斑狼疮(SLE)是一种复杂的自身免疫性疾病,以机体免疫防御系统功能失调为特征:本研究旨在探讨NRIR在系统性红斑狼疮中的表达和诊断意义,并证明它是否参与了系统性红斑狼疮的进展:方法:研究涉及 110 名参与者,包括 55 名健康人和 55 名系统性红斑狼疮患者。采用 qRT-PCR 方法测量了 NRIR、miR-31-5p 和 ICAM-1 的表达水平。采用 ROC 曲线评估 NRIR 在系统性红斑狼疮患者中的诊断意义。利用皮尔逊相关分析探讨了 NRIR 与其他指标之间的关系。细胞因子包括 IL-4、IL-6、IL-21 和 IgG 水平,均采用 ELISA 方法进行评估。使用双荧光素酶报告实验验证了 NRIR 与 miR-31-5p 之间的相互作用:结果:在系统性红斑狼疮患者中观察到了 NRIR 的表达上调,具有诊断系统性红斑狼疮的功能。此外,NRIR的异常表达会影响系统性红斑狼疮患者CD4+T细胞的活力。NRIR可负向调节miR-31-5p的表达:结论:LncRNA NRIR可能是系统性红斑狼疮的潜在生物标志物,并可能参与系统性红斑狼疮的进展。
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LncRNA NRIR serves as a biomarker for systemic lupus erythematosus and participates in the disease progression.

Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by a malfunction of the body's immune defense system.

Objective: The objective of the present investigation was to examine the expression and diagnostic significance of NRIR in SLE and to prove whether it is involved in the progression of SLE.

Methods: The study involved 110 participants, including 55 healthy individuals and 55 SLE patients. The expression levels of NRIR, miR-31-5p, and ICAM-1 were measured using qRT-PCR. The ROC curve was performed to assess the diagnostic significance of NRIR in SLE patients. Pearson correlation analysis was utilized to explore the relationship between NRIR and other indicators. Cytokines including IL-4, IL-6, and IL-21, along with IgG levels, were assessed using ELISA. The interaction between NRIR and miR-31-5p was validated using a dual-luciferase reporter assay.

Result: Upregulated expression of NRIR was observed in individuals with SLE, serving a diagnostic function for SLE. Additionally, abnormal expression of NRIR impacted the viability of CD4+ T cells within SLE patients. NRIR could negatively modulate the expression of miR-31-5p.

Conclusion: LncRNA NRIR may be a potential biomarker for SLE and is likely involved in the progression of SLE.

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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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