人肝同种异体移植的高光谱成像,用于预测移植的初始功能。

IF 2.1 3区 医学 Q2 SURGERY Langenbeck's Archives of Surgery Pub Date : 2024-10-14 DOI:10.1007/s00423-024-03497-4
Franziska Vogt, Tristan Wagner, Shadi Katou, Felicia Kneifel, Thomas Vogel, Haluk Morgül, Philipp Houben, Philip Wahl, Andreas Pascher, Sonia Radunz
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引用次数: 0

摘要

目的:缺血再灌注损伤是人类肝移植(LT)中造成短期和长期移植物损伤的一个重要但难以评估的风险因素。高光谱成像(HSI)作为一种非侵入性、非电离性工具,能够将光学特性与器官微灌注联系起来。因此,我们在此对人类肝脏同种异体移植进行了一项研究,通过高光谱成像评估微灌注情况并预测移植器官的初始功能:方法:37 例人肝脏同种异体移植物的肝实质图像是在工作台准备、常温机器灌注(如适用)期间以及受体再灌注后采集的。专门的 HSI 采集软件计算血氧饱和度 (StO2)、组织血红蛋白指数 (THI)、近红外灌注指数 (NIR) 和组织水分指数 (TWI)。分析了血红蛋白指数参数与保存技术、再灌注顺序和早期移植物功能障碍(EAD)的差异:结果:器官保存采用NMP(31例)或静态冷藏(6例)技术。两组患者的人口统计学特征、供体特征、EAD发生率(NMP 36.7% vs. SCS 50%,p = 0.6582)和HSI参数在保存方法上具有可比性。在发生 EAD 的器官中,受体在 1、2 和 4 h NMP 和再灌注后的近红外显著较低(1 h NMP:18.6 [8.6-27.6] vs. 28.3 [22.5-39.4],p = 0.0468;2 h NMP:19.4 [8.7-30.4] vs. 37.1 [27.5-44.6],p = 0.0011;4 h NMP:26.0 [6.8-37.1] vs. 40.3 [32.3-49.9],p = 0.0080;再灌注:13.0 [11.5-34.3] vs. 30.6 [19.3-44.0],p = 0.0212):结论:在器官保存期间和受体体内对人类肝脏异体移植进行 HSI 评估是可行的。结论:在器官保存期间和受体体内进行 HSI 评估是可行的,NMP 期间和再灌注后的近红外可预测 EAD 的发生。有必要进行更大规模的试验,以评估这项新技术在人体LT中的应用。
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Hyperspectral imaging of human liver allografts for prediction of initial graft function.

Purpose: Ischemia reperfusion injury represents a significant yet difficult to assess risk factor for short- and long-term graft impairment in human liver transplantation (LT). As a non-invasive, non-ionizing tool, hyperspectral imaging (HSI) is capable of correlating optical properties with organ microperfusion. Hence, we here performed a study of human liver allografts assessed by HSI for microperfusion and prediction of initial graft function.

Methods: Images of liver parenchyma of 37 human liver allografts were acquired at bench preparation, during normothermic machine perfusion (NMP), if applicable, and after reperfusion in the recipient. A specialized HSI acquisition software computed oxygen saturation (StO2), tissue hemoglobin indices (THI), near infrared perfusion indices (NIR), and tissue water indices (TWI). HSI parameters were analyzed for differences with regard to preservation technique, reperfusion sequence and presence of early allograft dysfunction (EAD).

Results: Organ preservation was performed by means of NMP (n = 31) or static cold storage (SCS; n = 6). Patients' demographics, donor characteristics, presence of EAD (NMP 36.7% vs. SCS 50%, p = 0.6582), and HSI parameters were comparable between both groups of preservation method. In organs developing EAD, NIR at 1, 2, and 4 h NMP and after reperfusion in the recipient was significantly lower (1 h NMP: 18.6 [8.6-27.6] vs. 28.3 [22.5-39.4], p = 0.0468; 2 h NMP: 19.4 [8.7-30.4] vs. 37.1 [27.5-44.6], p = 0.0011; 4 h NMP: 26.0 [6.8-37.1] vs. 40.3 [32.3-49.9], p = 0.0080; reperfusion: 13.0 [11.5-34.3] vs. 30.6 [19.3-44.0], p = 0.0212).

Conclusion: HSI assessment of human liver allografts is feasible during organ preservation and in the recipient. NIR during NMP and after reperfusion might predict the onset of EAD. Larger trials are warranted for assessment of this novel technique in human LT.

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来源期刊
CiteScore
3.30
自引率
8.70%
发文量
342
审稿时长
4-8 weeks
期刊介绍: Langenbeck''s Archives of Surgery aims to publish the best results in the field of clinical surgery and basic surgical research. The main focus is on providing the highest level of clinical research and clinically relevant basic research. The journal, published exclusively in English, will provide an international discussion forum for the controlled results of clinical surgery. The majority of published contributions will be original articles reporting on clinical data from general and visceral surgery, while endocrine surgery will also be covered. Papers on basic surgical principles from the fields of traumatology, vascular and thoracic surgery are also welcome. Evidence-based medicine is an important criterion for the acceptance of papers.
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