IF 0.6 4区 医学Q3 MEDICINE, GENERAL & INTERNALMedicina-buenos AiresPub Date : 2024-01-01
Paloma Garbelino Moliné, Matías Stringa, Javier Anaya, Carla Trila, José Trucco, Ana De Pablo
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引用次数: 0
摘要
关于大疱性类天疱疮(BP)与肿瘤之间的关系,医学文献中一直存在争议。尽管许多病例报告都描述了大疱性类天疱疮与各种肿瘤并存的情况,但病例对照研究却得出了相互矛盾的结果。我们介绍了一例男性患者的病例,他在被诊断为真菌病(MF)后不久就患上了良性前列腺增生症。他是一名 77 岁的男性,有 2 型糖尿病和高血压病史,被诊断为霉菌性真菌病。随后,他在日晒后出现了水疱,通过组织病理学和直接免疫荧光确诊为 BP。患者接受了泼尼松和甲氨蝶呤治疗,病情发展良好,没有复发MF或出现新的水疱。皮肤 T 细胞淋巴瘤与自身免疫性水疱病之间的关联非常罕见,但也有类似病例的报道,其中一些病例与光疗有关。在本病例中,BP 在日晒后发病,表明两者之间存在潜在联系。BP和MF并存仍存在争议,本病例强调了考虑肿瘤患者自身免疫性水疱病的重要性。
[Simultaneous presentation of bullous pemphigoid and mycosis fungoides].
The relationship between bullous pemphigoid (BP) and neoplasms has been debated in the medical literature. Although numerous case reports have described the coexistence of BP with various neoplasms, case-control studies have yielded conflicting results. We present the case of a male patient who developed BP shortly after being diagnosed with mycosis fungoides (MF). He was a 77-year-old man with a history of type 2 diabetes mellitus and hypertension who was diagnosed with MF. Subsequently, he developed blisters after sun exposure, and was diagnosed with BP through histopathology and direct immunofluorescence. The patient was treated with prednisone and methotrexate, with favorable evolution without recurrence of MF or appearance of new blisters. The association between cutaneous T-cell lymphoma and autoimmune blistering disease is rare, although similar cases have been reported, some associated with phototherapy. In this case, the onset of BP after sun exposure suggests a potential connection. The coexistence of BP and MF remains controversial, and this case highlights the importance of considering autoimmune blistering diseases in patients with oncohematological neoplasms.