细胞衰老:抑制牙周炎的新视角(综述)。

IF 3.4 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Molecular medicine reports Pub Date : 2024-12-01 Epub Date: 2024-10-18 DOI:10.3892/mmr.2024.13362
Xue-Jing Lin, Qing Yuan, Jie Zhou, Yu-Lei Dong, Diwas Sunchuri, Zhu-Ling Guo
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引用次数: 0

摘要

细胞衰老的特点是细胞周期停滞,当衰老细胞持续积累时,会导致组织功能障碍。牙周炎是一种慢性炎症,由细菌和宿主免疫系统相互作用引起,主要表现为牙周组织受损。衰老和炎症是相互关联的过程,会相互加重。局部慢性牙周炎症的进展往往会随着组织和器官的衰老而加速。衰老细胞的存在以及与衰老相关分泌表型有关的炎性细胞因子、免疫调节剂、生长因子和蛋白酶的释放,都会导致牙周组织的恶化。本综述旨在阐明细胞衰老的机制及其对牙周炎的潜在影响,为调节牙周组织的炎症微环境提供新的见解。
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Cellular senescence: A new perspective on the suppression of periodontitis (Review).

Cellular senescence, characterized by cell cycle arrest, can result in tissue dysfunction when senescent cells persist and accumulate. Periodontitis, a chronic inflammatory condition caused by the interaction between bacteria and the immune system of the host, primarily manifests as damage to periodontal tissues. Aging and inflammation are interlinked processes that exacerbate each other. The progression of localized chronic periodontal inflammation is often accelerated in conjunction with tissue and organ aging. The presence of senescent cells and release of inflammatory cytokines, immune modulators, growth factors and proteases that are associated with the senescence‑associated secretory phenotype contribute to the deterioration of periodontal tissues. The present review aimed to elucidate the mechanisms of cellular senescence and its potential impact on periodontitis, offering novel insights for modulating the inflammatory microenvironment of periodontal tissues.

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来源期刊
Molecular medicine reports
Molecular medicine reports 医学-病理学
CiteScore
7.60
自引率
0.00%
发文量
321
审稿时长
1.5 months
期刊介绍: Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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