乳腺癌血液中微生物群和肠道微生物代谢物的综合分析。

IF 5 2区 生物学 Q1 MICROBIOLOGY mSystems Pub Date : 2024-10-18 DOI:10.1128/msystems.00643-24
Yu Peng, Jiale Gu, Fubin Liu, Peng Wang, Xixuan Wang, Changyu Si, Jianxiao Gong, Huijun Zhou, Ailing Qin, Fangfang Song
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引用次数: 0

摘要

肠道微生物群和相关代谢物与乳腺癌的发生有关。有证据表明,血液微生物群主要来自肠道,可作为乳腺癌的生物标志物。我们的目的是描述血液中微生物群-肠道微生物代谢物交叉作用的特征,并开发一个乳腺癌综合诊断面板。我们对 107 例乳腺癌病例和 107 例年龄配对对照的血液样本进行了 16S rRNA 基因测序和代谢组学分析。我们发现,与对照组相比,乳腺癌患者血液微生物群的α多样性降低了。这两组患者血液中的微生物群和肠道微生物代谢物有明显差异,患者血液中的九个细菌属和四个肠道微生物代谢物增加,而对照组血液中的三十九个细菌属和两个肠道微生物代谢物增加。一些与乳腺癌相关的肠道微生物代谢物与不同的血液微生物群相关联,并进一步开发了一个复合微生物群-代谢物诊断面板,对乳腺癌的曲线下面积为 0.963。这项研究强调了血液中的微生物群和肠道微生物代谢物及其相互作用对乳腺癌发生的关键作用,以及复合诊断面板作为乳腺癌非侵入性生物标志物的潜力。血液中微生物群和肠道微生物代谢物之间的广泛相关性有助于了解乳腺癌的发病机制。血液中微生物群-肠道微生物代谢物复合面板的良好性能表明,这是一种非侵入性的乳腺癌检测方法,也是未来更好地诊断和预防乳腺癌的一种新策略。
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Integrated analysis of microbiota and gut microbial metabolites in blood for breast cancer.

Gut microbiota and associated metabolites have been linked to breast carcinogenesis. Evidences demonstrate blood microbiota primarily originates from the gut and may act as a biomarker for breast cancer. We aimed to characterize the microbiota-gut microbial metabolites cross-talk in blood and develop a composite diagnostic panel for breast cancer. We performed 16S rRNA gene sequencing and metabolomics profiling on blood samples from 107 breast cancer cases and 107 age-paired controls. We found that the alpha diversity of the blood microbiota was decreased in breast cancer compared to controls. There were significantly different profiles of microbiota and gut microbial metabolites in blood between these two groups, with nine bacterial genera and four gut microbial metabolites increased in patients, while thirty-nine bacterial genera and two gut microbial metabolites increased in controls. Some breast cancer-associated gut microbial metabolites were linked to differential blood microbiota, and a composite microbiota-metabolite diagnostic panel was further developed with an area under the curve of 0.963 for breast cancer. This study underscored the pivotal role of microbiota and gut microbial metabolites in blood and their interactions for breast carcinogenesis, as well as the potential of a composite diagnostic panel as a non-invasive biomarker for breast cancer.IMPORTANCEOur integrated analysis demonstrated altered profiles of microbiota and gut microbial metabolites in blood for breast cancer patients. The extensive correlation between microbiota and gut microbial metabolites in blood assisted the understanding of the pathogenesis of breast cancer. The good performance of a composite microbiota-gut microbial metabolites panel in blood suggested a non-invasive approach for breast cancer detection and a novel strategy for better diagnosis and prevention of breast cancer in the future.

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来源期刊
mSystems
mSystems Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
10.50
自引率
3.10%
发文量
308
审稿时长
13 weeks
期刊介绍: mSystems™ will publish preeminent work that stems from applying technologies for high-throughput analyses to achieve insights into the metabolic and regulatory systems at the scale of both the single cell and microbial communities. The scope of mSystems™ encompasses all important biological and biochemical findings drawn from analyses of large data sets, as well as new computational approaches for deriving these insights. mSystems™ will welcome submissions from researchers who focus on the microbiome, genomics, metagenomics, transcriptomics, metabolomics, proteomics, glycomics, bioinformatics, and computational microbiology. mSystems™ will provide streamlined decisions, while carrying on ASM''s tradition of rigorous peer review.
期刊最新文献
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