功能性运动障碍与脑深部刺激：综述。

IF 2.3 Q3 CLINICAL NEUROLOGY Neurology. Clinical practice Pub Date : 2025-02-01 Epub Date: 2024-10-08 DOI:10.1212/CPJ.0000000000200367

Alexandra Boogers, Alfonso Fasano

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引用次数: 0

摘要

综述的目的：本综述旨在探讨功能性运动障碍（FMD）与脑深部刺激（DBS）之间的相互作用：最新研究结果：未被发现的功能性运动障碍患者在转诊接受 DBS 治疗时通常表现为功能性肌张力障碍。相比之下，接受 DBS 治疗后出现 FMD 的患者大多伴有功能性震颤，这与未接受 DBS 治疗的 FMD 患者群一致。在已确定的 DBS 适应症中合并出现 FMD，这使得选择手术的决定变得具有挑战性。许多因素都可能导致 FMD 的发生，包括清醒神经外科手术和/或大量 DBS 编程造成的创伤：DBS 中的 FMD 常常被忽视，应及时诊断，因为它们决定着手术结果。对合并 FMD 的 DBS 候选者的治疗方法以及 DBS 术后 FMD 的风险因素应进一步探讨。

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Functional Movement Disorders and Deep Brain Stimulation: A Review.

Purpose of the review: The aim of this narrative review was to explore the interplay between functional movement disorders (FMDs) and deep brain stimulation (DBS).

Recent findings: Patients with unrecognized FMD who are referred for DBS usually present with functional dystonia. By contrast, patients who present with FMD after DBS are mostly presenting with functional tremor, in keeping with non-DBS FMD cohorts. Comorbid presentation of FMD in established DBS indications makes the decision to opt for surgery challenging. Many contributing factors can play a role in the development of FMD, including the trauma caused by awake neurosurgery and/or extensive DBS programming.

Summary: FMDs in the context of DBS are often overlooked and should be diagnosed promptly because they determine surgical outcome. The approach to DBS candidates with comorbid FMD and the risk factors of FMD after DBS should be further explored.

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来源期刊

Neurology. Clinical practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

0.00%

发文量

期刊介绍： Neurology® Genetics is an online open access journal publishing peer-reviewed reports in the field of neurogenetics. The journal publishes original articles in all areas of neurogenetics including rare and common genetic variations, genotype-phenotype correlations, outlier phenotypes as a result of mutations in known disease genes, and genetic variations with a putative link to diseases. Articles include studies reporting on genetic disease risk, pharmacogenomics, and results of gene-based clinical trials (viral, ASO, etc.). Genetically engineered model systems are not a primary focus of Neurology® Genetics, but studies using model systems for treatment trials, including well-powered studies reporting negative results, are welcome.