决定患者骨折风险决策点(FRDP)的临床和人口因素:改善骨质疏松症风险交流(RICO)项目。

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Osteoporosis International Pub Date : 2024-10-21 DOI:10.1007/s00198-024-07264-5
Mitali Sharma, Charlotte Beaudart, Patricia Clark, Saeko Fujiwara, Jonathan D Adachi, Alexandra Papaioannou, Osvaldo D Messina, Suzanne N Morin, Lynn Kohlmeier, Xavier Nogues, Carolyn Leckie, Nicholas C Harvey, John A Kanis, Jean-Yves Reginster, Mickael Hiligsmann, Stuart L Silverman
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引用次数: 0

摘要

本研究旨在了解不同国家对骨质疏松症药物治疗阈值的接受程度有何差异,以及临床和人口因素的影响。在骨折概率达到或低于治疗阈值时,共有 79.2% 的人接受了治疗。目的:"改善骨质疏松症的风险沟通"(RICO)研究的这一部分旨在了解患者在假定骨折概率来自 FRAX® 风险评估工具的情况下开始骨质疏松症治疗的意愿,以及年龄、骨折史和数字素养如何影响这一意愿:2022-2023 年,我们对来自 9 个国家的 332 名面临骨折风险的绝经后妇女进行了访谈,以确定参与者的骨折风险决策点(FRDP),即她们愿意接受骨质疏松症药物治疗的最低骨质疏松性骨折概率。根据八个假设的 10 年 FRAX 分数对参与者的 FRDP 进行了评估:结果:在采用基于 FRAX 的治疗阈值的国家中,每个国家有一半以上的参与者报告的 FRDP 低于阈值。总的来说,79.2%的人的FRDP达到或低于各自的阈值。年龄和骨折史对 FRDP 的影响并不大;但是,与数字识字水平较低者相比,数字识字水平较高者报告的 FRDP 中位数(10%)明显较高(5%,p 结论:大多数患者愿意接受骨科治疗:大多数患者愿意接受假定 FRAX 概率甚至低于国家推荐治疗阈值的骨质疏松症药物处方。文化程度评分对 FRDP 有显著影响,而年龄和骨折史则没有影响。
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Clinical and demographic factors determining patient fracture risk decision point (FRDP): The improving risk communication in osteoporosis (RICO) project.

This study aims to understand how osteoporosis medication acceptance varies across countries with differing guidance on treatment threshold and influence of clinical and demographic factors. A total of 79.2% accepted treatment at a fracture probability at or below the treatment threshold. Fracture history and age did not strongly impact acceptance, suggesting a need for improved fracture risk communication.

Purpose: This part of the Improving Risk Communication in Osteoporosis (RICO) study aims to understand patients' willingness to initiate osteoporosis treatment given a hypothetical fracture probability-derived from the FRAX® Risk Assessment Tool-and how age, fracture history, and numeric literacy may influence this.

Methods: In 2022-2023, 332 postmenopausal women at risk of fracture were interviewed from nine countries to determine participants' Fracture Risk Decision Point (FRDP), the lowest probability of major osteoporotic fracture at which they would accept an osteoporosis medication. Participants' FRDP was evaluated given eight hypothetical 10-year FRAX scores.

Results: In countries with FRAX-based treatment thresholds, over half of the participants per country reported an FRDP that was below the threshold. Collectively, 79.2% demonstrated FRDPs at or below their respective threshold. Age and fracture history did not have a strong influence on FRDP; however, those who demonstrated higher levels of numeric literacy reported a significantly higher median FRDP (10%) compared to those who showed lower levels (5%, p < 0.001).

Conclusions: Most patients were willing to accept an osteoporosis medication prescription at a hypothetical FRAX probability that was even lower than that of their nationally recommended treatment threshold. Literacy scores had a significant influence on FRDP whereas age and fracture history did not.

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来源期刊
Osteoporosis International
Osteoporosis International 医学-内分泌学与代谢
CiteScore
8.10
自引率
10.00%
发文量
224
审稿时长
3 months
期刊介绍: An international multi-disciplinary journal which is a joint initiative between the International Osteoporosis Foundation and the National Osteoporosis Foundation of the USA, Osteoporosis International provides a forum for the communication and exchange of current ideas concerning the diagnosis, prevention, treatment and management of osteoporosis and other metabolic bone diseases. It publishes: original papers - reporting progress and results in all areas of osteoporosis and its related fields; review articles - reflecting the present state of knowledge in special areas of summarizing limited themes in which discussion has led to clearly defined conclusions; educational articles - giving information on the progress of a topic of particular interest; case reports - of uncommon or interesting presentations of the condition. While focusing on clinical research, the Journal will also accept submissions on more basic aspects of research, where they are considered by the editors to be relevant to the human disease spectrum.
期刊最新文献
Correction: Exposure to air pollution might decrease bone mineral density and increase the prevalence of osteoporosis: A mendelian randomization study. Type 2 diabetes incidence in patients initiating denosumab or alendronate treatment: a primary care cohort study. Real-world efficacy of a teriparatide biosimilar (RGB-10) compared with reference teriparatide on bone mineral density, trabecular bone score, and bone parameters assessed using quantitative ultrasound, 3D-SHAPER® and high-resolution peripheral computer tomography in postmenopausal women with osteoporosis and very high fracture risk. One versus 2 years of alendronate following denosumab: the CARD extension. Association of proton-density fat fraction with osteoporosis: a systematic review and meta-analysis.
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