一名儿科患者中毒性表皮坏死溶解后的播散性爆发性黑素细胞痣和指甲变化：病例报告和文献系统性综述。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-10-10 DOI:10.1111/pde.15777

Scott C Jaros, Dean S Morrell, Elizabeth L Nieman

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引用次数: 0

摘要

据报道，爆发性黑素细胞痣（EMN）可在免疫抑制、化疗和牛皮癣（包括较少见的史蒂文斯-约翰逊综合征（SJS）和中毒性表皮坏死（TEN））的情况下出现。本病例报告介绍了一名 4 岁女孩在 TEN 后出现的带状 EMN 和指甲变化。对文献的系统性回顾支持对 EMN 进行适当的临床随访，因为目前还没有关于 SJS/TEN 后 EMN 发生恶性肿瘤的报道，也没有关于任何病因引起的小儿黑色素瘤的报道。进一步研究指甲变化与 EMN 发生的可能相关性，并更好地描述 EMN 的皮肤镜特征，可以改善对这些患者的监测和护理。

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Agminated Eruptive Melanocytic Nevi and Nail Changes Following Toxic Epidermal Necrolysis in a Pediatric Patient: A Case Report and Systematic Review of the Literature.

Eruptive melanocytic nevi (EMN) have been reported in the setting of immunosuppression, chemotherapy, and bullous skin disease, including less commonly, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). This case report presents a 4-year-old girl who developed agminated EMN and nail changes after TEN. A systematic review of the literature supports clinically appropriate follow-up of EMN, as there is no reports of malignancy in EMN following SJS/TEN, nor reports of pediatric melanoma arising within EMN of any etiology. Further study of the possible correlation of nail changes with the development of EMN and better characterization of the dermoscopic features of EMN could improve monitoring and care of these patients.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.