新生儿皮肤屏障功能的变化：每日变化和沐浴的影响

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-10-17 DOI:10.1111/pde.15772

Fumi Tanaka, Chiemi Hayashi, Mayumi Iida, Kimika Shinya, Masaki Futamura

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引用次数: 0

摘要

背景：皮肤屏障功能是预测新生儿屏障缺陷的重要指标。本研究旨在调查新生儿皮肤屏障功能的日常变化以及洗澡对皮肤屏障功能的影响：我们评估了新生儿出生后第 2 到 7 天和 1 个月时前额、脸颊、前臂和胸部的经表皮失水率 (TEWL) 和角质层水合率 (SCH)。此外，我们还测量了洗澡后的数值，并与洗澡前的数值进行了比较：结果：66 名新生儿参与了评估，四个部位的每个数值都显示出显著的相关性。在第 2 天和第 7 天之间，TEWL 保持稳定，但 SCH 在大多数部位显著增加。在 1 个月内，两者都明显增加了 1.5-2 倍。沐浴后，TEWL 增加了 20% 以上，但 3 小时后又下降了：结论：在出生后的第一周，TEWL并没有随着年龄的增长而发生明显变化。为尽量减少洗澡的影响，应在洗澡后至少 3 小时测量 TEWL。

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Changes in Skin Barrier Function in Neonates: Daily Variation and Impact of Bathing.

Background: The skin barrier function is an important predictor of neonatal barrier defects. This study aimed to investigate the daily changes in skin barrier function and the impact of bathing on skin barrier function in neonates.

Methods: We assessed the transepidermal water loss (TEWL) and stratum corneum hydration (SCH) on the forehead, cheek, volar forearm, and chest from days 2 to 7 and at 1 month after birth. Additionally, we measured the values after bathing and compared them with the pre-bathing values.

Results: Sixty-six neonates were involved in the assessment, and each value at the four sites showed significant correlations. TEWL remained stable between days 2 and 7, but SCH significantly increased at most sites. Both significantly increased by 1.5-2 times in 1 month. After bathing, TEWL increased by more than 20% but decreased again after 3 h.

Conclusions: TEWL did not change significantly with age during the first week of life. To minimize the effects of bathing, TEWL should be measured at least 3 h after bathing.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.