肾移植术后早期尿路感染的独立风险因素是围手术期累积的兔抗人胸腺细胞球蛋白剂量与受体体重之比。

IF 3 3区 医学 Q1 UROLOGY & NEPHROLOGY Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-10-16 DOI:10.1080/0886022X.2024.2414841
Shujuan Li, Ziyu Wang, Zhen Dong, Yanwei Cao, Hongyang Wang
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引用次数: 0

摘要

抗人胸腺细胞球蛋白-费森尤斯(ATG-F)经常用于肾移植受者的成功诱导。本研究旨在探讨ATG-F剂量与受者体重比(ADR)与肾移植术后发生尿路感染(UTI)风险之间的关系。研究人员回顾性收集了一家医疗中心围手术期接受ATG-F诱导的肾移植受者的数据,并记录了术后第一年的UTI发病率。分析了与 ADR 相关的 UTI 风险,并绘制了接收者操作特征曲线以确定最佳 ADR,随后建立了 Cox 回归模型。共纳入了 131 名受术者,UTI 发生率为 19.08%,平均间隔时间为 3.08 个月。最佳 ADR 为 6.34,低 ADR 组和高 ADR 组分别有 41 和 90 名患者。低 ADR 组的无尿毒症率明显高于高 ADR 组(P = 0.007)。Cox 回归分析表明,高 ADR 会独立增加肾移植后发生 UTI 的风险(危险比:5.306,95% 置信区间:1.243-22.660,p = 0.024)。高 ADR 组和低 ADR 组的排斥率没有明显差异。总之,高 ADR 会增加肾移植受者术后早期尿毒症的发病率。
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Cumulative rabbit anti-human thymocyte globulin dose to recipient weight during the peri-operative period is an independent risk factor for early postoperative urinary tract infection after kidney transplantation.

Anti-human thymocyte globulin-Fresenius (ATG-F) is frequently utilized to achieve successful induction for kidney transplantation recipients. This study aimed to examine the association between the ATG-F dose-to-recipient-weight ratio (ADR) and the risk of developing urinary tract infections (UTIs) following kidney transplantation. Data of kidney transplant recipients who underwent ATG-F-induction peri-operatively in a medical center were retrospectively collected, and the incidence of UTIs during the first postoperative year was also recorded. The risk of UTI associated with ADR was analyzed, and receiver operating characteristic curves were drawn to determine the optimal ADR, followed by Cox regression models. In total, 131 recipients were included, with an UTI incidence of 19.08% and a mean interval of 3.08 months. The optimal ADR was 6.34, involving 41 and 90 patients in the low ADR and high ADR groups, respectively. The UTI-free rate in the low ADR group was significantly higher than that in the high ADR group (p = 0.007). Cox regression analysis indicated that a high ADR independently increased the risk of UTI following kidney transplantation (hazard ratio: 5.306, 95% confidence interval: 1.243-22.660, p = 0.024). There was no significant difference in rejection rate between the high ADR and low ADR groups. In conclusion, a high ADR increased the incidence of early postoperative UTI among kidney transplant recipients.

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来源期刊
Renal Failure
Renal Failure 医学-泌尿学与肾脏学
CiteScore
3.90
自引率
13.30%
发文量
374
审稿时长
1 months
期刊介绍: Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.
期刊最新文献
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