代餐对肥胖和瘦素的影响:系统回顾和荟萃分析。

IF 6.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-10-21 DOI:10.1007/s11154-024-09918-5
Somaye Fatahi, Danial Fotros, Mohammad Hassan Sohouli, Koroush Vahidshahi, Pejman Rohani, Nathalia Sernizon Guimarães
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引用次数: 0

摘要

肥胖和超重在全球的流行是公共卫生领域的一个重大问题。为了评估代餐(MRs)对反映肥胖的人体测量指标和指数以及实验室测试可能产生的影响,已经开展了大量干预性研究。然而,在这一领域还没有全面的结果。本研究旨在了解代餐对体重、体重指数(BMI)、脂肪量、腰围(WC)和瘦素水平可能产生的影响。研究人员在五个电子数据库中进行了系统搜索,以找到研究 MRs 对肥胖可能产生的影响的随机临床试验 (RCT)。分析使用 4.2.1 版 R 软件进行。随机效应模型分析用于提供集合平均差和 95% 置信区间 (95%CI)。共纳入 70 项研究。与对照组相比,MRs 后体重(WMD:-3.35 千克,95% CI:-4.28 至 -2.42)、BMI(WMD:-1.12 千克/平方米,95% CI:-1.51 至 -0.72)、脂肪量(WMD:-2.77 千克,95% CI:-3.59 至 -1.6)、WC(WMD:-2.82 厘米,95% CI:-3.51 至 -2.12)显著降低。对瘦素(WMD:-3.37 纳克/毫升,95% CI:-8.23 至 1.49)未观察到明显影响。分组分析表明,与部分 MRs 相比,全部 MRs 对人体测量因素的影响更大。考虑到其他生活方式因素,MR 可导致人体测量指标和指数下降。
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Meal replacements on obesity and leptin: a systematic review and meta-analysis.

The global prevalence of obesity and overweight is a significant concern in the field of public health. Numerous interventional studies have been conducted to assess the possible meal replacements (MRs) effect on anthropometric indicators and indices and laboratory test that reflect obesity. However, there are no comprehensive results in this field. The study aim was to understand the possible effects of MRs on body weight, body mass index (BMI), fat mass, waist circumferences (WC), and leptin levels. A systematic search was conducted in five electronic databases in order to find randomized clinical trials (RCTs) that examined the possible MRs effect on obesity. Analyses were performed in R software, version 4.2.1. The random-effects model analysis was used to provide pooled mean difference and 95% confidence intervals (95% CI). Seventy studies were included. Body weight (WMD: -3.35 kg, 95% CI: -4.28 to -2.42), BMI (WMD: -1.12 kg/m2, 95% CI: -1.51 to -0.72), fat mass (WMD: -2.77 kg, 95% CI: -3.59 to -1.6), WC (WMD: -2.82 cm, 95% CI: -3.51 to -2.12) were significantly reduced after MRs compared to control. No significant effect was observed on leptin (WMD: -3.37 ng/ml, 95% CI: -8.23 to 1.49). Subgroup analyses indicated that impact of total MRs on anthropometric factors was greater in comparison to partial MRs. Considering other lifestyle factors, MRs can lead to anthropometric indicators and indices reduction.

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来源期刊
Reviews in Endocrine & Metabolic Disorders
Reviews in Endocrine & Metabolic Disorders 医学-内分泌学与代谢
CiteScore
14.70
自引率
1.20%
发文量
75
审稿时长
>12 weeks
期刊介绍: Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to the field of endocrinology and metabolism. It aims to provide the latest advancements in this rapidly advancing field to students, clinicians, and researchers. Unlike other journals, each quarterly issue of this review journal focuses on a specific topic and features ten to twelve articles written by world leaders in the field. These articles provide brief overviews of the latest developments, offering insights into both the basic aspects of the disease and its clinical implications. This format allows individuals in all areas of the field, including students, academic clinicians, and practicing clinicians, to understand the disease process and apply their knowledge to their specific areas of interest. The journal also includes selected readings and other essential references to encourage further in-depth exploration of specific topics.
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