Marcus Ground, Thijmen Veenendaal, Daniel Rexie Chiluzi, Geoffrey Nkhonjera, Arie C Glas, Lisanne Glas-van Dijk
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引用次数: 0
摘要
我们报告了一例艾滋病病毒（HIV）阳性男性患者的病例，他被诊断患有与人类疱疹病毒 8（HHV8）感染相关的多中心卡斯特曼病（MCD），并并发了肾功能衰竭。这种原本罕见的疾病的亚型是 HIV 和 HHV8 感染的并发症。在发展中国家，HHV8-MCD 的诊断和治疗具有挑战性，部分原因是其罕见性，但主要原因是组织学和其他实验室服务的获取途径有限。我们的病例出现了一系列令人困惑的症状，经组织学检查确诊为 MCD。在此，我们讨论了在资源有限的环境中，HIV感染背景下HHV8-MCD的流行病学、发病机制、诊断和治疗，希望通过提高人们对该病的认识，能够更及时地识别该病。
HHV8-Associated Multicentric Castleman Disease: A Case Report on a Rare Complication of HIV in a Low-Income Setting.
We present the case of an HIV-positive man diagnosed with multicentric Castleman disease (MCD) associated with human herpesvirus 8 (HHV8) infection, complicated by renal failure. This subtype of an otherwise rare disease is a complication of HIV and HHV8 infection. The diagnosis and management of HHV8-MCD in the developing world is challenging-in part due to its rarity, but largely due to the limited access to histology and other laboratory services. Our case presented with a confusing constellation of symptoms and was diagnosed with MCD on histology. Here we discuss the epidemiology, pathogenesis, diagnosis, and treatment of HHV8-MCD in the context of HIV infection in a resource-limited setting, in the hope that greater awareness will lead to more prompt recognition.
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