从癌症的标志看髓细胞转化。

IF 11.5 Q1 HEMATOLOGY Blood Cancer Discovery Pub Date : 2024-11-01 DOI:10.1158/2643-3230.BCD-24-0009
Inés Fernández-Maestre, Sheng F Cai, Ross L Levine
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引用次数: 0

摘要

髓系恶性肿瘤的发展受到一系列细胞内在和细胞外在因素的影响,这些因素可以用癌症的特征来概念化。尽管髓系恶性肿瘤转化的许多方面与实体瘤相似,但也存在明显差异。与实体瘤不同,血液系统恶性肿瘤通常表现出较少的基因突变,这些基因突变已被很好地描述。然而,由于造血微环境中复杂的相互作用,了解导致骨髓恶性肿瘤的细胞外在因素可能具有挑战性。研究人员需要关注这些错综复杂的因素,以预防髓系转化的早期发生并制定适当的干预措施。意义重大:髓系恶性肿瘤在老年人中很常见,急性髓系白血病在老年患者中预后不良。研究影响髓系恶性肿瘤的细胞外在因素对于开发预防或阻止疾病进展的方法以及预测晚期患者的临床预后至关重要。成功的干预可能需要针对各种机制,而了解每种细胞外在因素的作用将有助于确定临床目标的优先次序。
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A View of Myeloid Transformation through the Hallmarks of Cancer.

The development of myeloid malignancies is influenced by a range of cell-intrinsic and cell-extrinsic factors, which can be conceptualized using the hallmarks of cancer. Although many facets of myeloid transformation are similar to those in solid tumors, there are also notable differences. Unlike solid tumors, hematologic malignancies typically exhibit fewer genetic mutations, which have been well characterized. However, understanding the cell-extrinsic factors contributing to myeloid malignancies can be challenging due to the complex interactions in the hematopoietic microenvironment. Researchers need to focus on these intricate factors to prevent the early onset of myeloid transformation and develop appropriate interventions. Significance: Myeloid malignancies are common in the elderly, and acute myeloid leukemia has an adverse prognosis in older patients. Investigating cell-extrinsic factors influencing myeloid malignancies is crucial to developing approaches for preventing or halting disease progression and predicting clinical outcomes in patients with advanced disease. Whereas successful intervention may require targeting various mechanisms, understanding the contribution of each cell-extrinsic factor will help prioritize clinical targets.

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来源期刊
CiteScore
12.70
自引率
1.80%
发文量
139
期刊介绍: The journal Blood Cancer Discovery publishes high-quality Research Articles and Briefs that focus on major advances in basic, translational, and clinical research of leukemia, lymphoma, myeloma, and associated diseases. The topics covered include molecular and cellular features of pathogenesis, therapy response and relapse, transcriptional circuits, stem cells, differentiation, microenvironment, metabolism, immunity, mutagenesis, and clonal evolution. These subjects are investigated in both animal disease models and high-dimensional clinical data landscapes. The journal also welcomes submissions on new pharmacological, biological, and living cell therapies, as well as new diagnostic tools. They are interested in prognostic, diagnostic, and pharmacodynamic biomarkers, and computational and machine learning approaches to personalized medicine. The scope of submissions ranges from preclinical proof of concept to clinical trials and real-world evidence. Blood Cancer Discovery serves as a forum for diverse ideas that shape future research directions in hematooncology. In addition to Research Articles and Briefs, the journal also publishes Reviews, Perspectives, and Commentaries on topics of broad interest in the field.
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