新辅助免疫化疗后进行原位肺自体移植(Oto 手术)治疗中央型肺癌:病例报告与文献综述。

IF 0.8 Q4 RESPIRATORY SYSTEM Respirology Case Reports Pub Date : 2024-10-11 eCollection Date: 2024-10-01 DOI:10.1002/rcr2.70045
Po-Keng Su, Chen-Chieh Lin, Szu-Yen Hu, Ming-Hsien Lin, Chun-Yu Wu, Shun-Mao Yang, Takahiro Oto
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引用次数: 0

摘要

袖式和双袖式肺叶切除术是治疗中央型肺癌的保肺技术。然而,如果肿瘤扩展到涉及支气管和血管,肺自体移植可能是肺切除术的替代方法。手术后的新辅助治疗是治疗范围广泛的中央型肺癌患者最常用的策略。在此,我们报告了一例在肺自体移植术后接受免疫化疗作为新辅助治疗的中央型肺癌患者。一名 68 岁的男性患者患有 IIIA 期非小细胞肺癌和左上叶鳞状细胞癌,接受了新辅助免疫化疗。在肺癌部分消退后,多学科团队决定在肺切除术后进行自体肺移植,以保留肺功能。患者恢复顺利,三周后出院,没有肿瘤残留或淋巴结转移。肺自体移植可以在非肺移植中心成功进行,这有可能拓宽中心型肺癌患者的治疗选择。
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Neoadjuvant immunochemotherapy followed by ex situ lung auto-transplant (Oto procedure) for central lung cancer: A case report with literature review.

Sleeve and double-sleeve lobectomies are lung-sparing techniques for treating central lung cancers. However, if the tumour extends to involve the bronchi and vessels, lung auto-transplantation may be an alternative to pneumonectomy. Neoadjuvant therapy after surgery is the most common strategy for patients with extensive central lung cancer. Herein, we report a case of central lung cancer in a patient who underwent immunochemotherapy as neoadjuvant therapy following lung auto-transplantation. A 68-year-old man with stage IIIA non-small cell lung cancer and left upper lobe squamous cell carcinoma underwent neoadjuvant immunochemotherapy. Following partial regression, a multidisciplinary team decided on a back-table procedure with auto-lung transplantation after pneumonectomy to preserve pulmonary function. The patient had an uneventful recovery and was discharged after three weeks with no residual tumour or lymph node metastases. Lung auto-transplantation can be successfully performed in non-lung transplantation centres, potentially broadening treatment options for patients with central lung cancer.

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来源期刊
Respirology Case Reports
Respirology Case Reports RESPIRATORY SYSTEM-
CiteScore
1.40
自引率
0.00%
发文量
178
审稿时长
8 weeks
期刊介绍: Respirology Case Reports is an open-access online journal dedicated to the publication of original clinical case reports, case series, clinical images and clinical videos in all fields of respiratory medicine. The Journal encourages the international exchange between clinicians and researchers of experiences in diagnosing and treating uncommon diseases or diseases with unusual presentations. All manuscripts are peer-reviewed through a streamlined process that aims at providing a rapid turnaround time from submission to publication.
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