D-二聚体作为转移性乳腺癌患者化疗反应的预测性生物标记物

IF 3.4 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Biomarker Insights Pub Date : 2024-10-17 eCollection Date: 2024-01-01 DOI:10.1177/11772719241290704
Lubana Alkhoder, Maher Salamoon, Maher Saifo, Sulaf Alwassouf
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引用次数: 0

摘要

背景:肿瘤诱导凝血在癌症患者中广泛存在。此外,肿瘤诱导凝血与肿瘤发生、肿瘤进展和转移有关,因为它创造了一个增殖和促血管生成的微环境。因此,纤维蛋白降解产物 D-二聚体与多种癌症类型的肿瘤预后相关:本研究旨在探讨 D-二聚体水平是否可作为转移性乳腺癌(MBC)患者化疗反应的预测和监测指标:设计:这是一项前瞻性研究:本研究包括两组患者,分别是76名确诊为转移性乳腺癌的患者和25名原发性乳腺癌患者。在开始化疗前和第四个治疗周期后,对 MBC 患者的血浆 D-二聚体水平进行前瞻性测量。使用接收者操作特征曲线(ROC)分析化疗前(D0)的D-二聚体水平,以确定D0的最佳临界基线值,并评估其预测化疗反应的判别能力:在初步反应评估中,部分反应模式患者的 D-二聚体平均水平明显下降了 0.65 μg/ml,病情稳定患者的 D-二聚体平均水平下降了 0.5 μg/ml。在疾病进展组中,D-二聚体水平明显增加了 1.2 μg/ml。ROC曲线分析表明,D0时的D-二聚体水平可判别对化疗的反应,而疾病进展率与较高的D-二聚体水平相关:结论:血浆中的D-二聚体水平是预测和监测转移性乳腺癌化疗反应的有效指标。
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D-dimer as a Predictive Biomarker of Response to Chemotherapy in Patients With Metastatic Breast Cancer.

Background: Tumor-induced coagulation is widely observed in cancer patients. Moreover, it is associated with tumorigenesis, tumor progression and metastasis, by creating a proliferative and proangiogenic microenvironment. Therefore, D-dimer, a fibrin degradation product, correlates with tumor prognosis in several cancer types.

Objectives: This study aims to investigate whether D-dimer levels can be a predictive and monitoring indicator for chemotherapy response in metastatic breast cancer (MBC) patients.

Design: This was a prospective study.

Methods: This study included two groups, 76 patients diagnosed with metastatic breast carcinoma and 25 patients with primary breast carcinoma. Plasma D-dimer levels were measured prospectively before chemotherapy initiation, and after the fourth treatment cycle in MBC patients. D-dimer levels before chemotherapy (D0) were analyzed using Receiver Operating Characteristic (ROC) curves to determine the optimal cut-off baseline values of D0, and to evaluate their discriminatory abilities in predicting response to chemotherapy.

Results: In the preliminary response evaluation, the mean level of D-dimer significantly decreased by 0.65 μg/ml in patients with partial response patterns, and by 0.5 μg/ml in patients with stable disease. In the disease progression group, a marked increase was seen in D-dimer levels by 1.2 μg/ml. Analysis of ROC curves showed that D-dimer levels at D0 could discriminate the response to chemotherapy, whereas progressive disease rate correlated with higher levels of D-dimer.

Conclusion: D-dimer level in plasma is a useful predictive and monitoring marker of response to chemotherapy in metastatic breast cancer.

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来源期刊
Biomarker Insights
Biomarker Insights MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
6.00
自引率
0.00%
发文量
26
审稿时长
8 weeks
期刊介绍: An open access, peer reviewed electronic journal that covers all aspects of biomarker research and clinical applications.
期刊最新文献
Decreased Serum Insulin Receptor Messenger RNA Level in H. pylori IgG Seropositive Type 2 Diabetic Patients. Systematic Analysis and Insights Into the Mutation Spectrum and Ethnic Differences in ATP7B Mutations Associated With Wilson Disease. The Chromosome Passenger Complex (CPC) Components and Its Associated Pathways Are Promising Candidates to Differentiate Between Normosensitive and Radiosensitive ATM-Mutated Cells. D-dimer as a Predictive Biomarker of Response to Chemotherapy in Patients With Metastatic Breast Cancer. Biomarkers From Discovery to Clinical Application: In Silico Pre-Clinical Validation Approach in the Face of Lung Cancer.
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