Lili Wang, Le Cheng, Chenhui Lv, Jie Kou, Wenjuan Feng, Haoran Xie, Ruolin Yan, Xi Wang, Shuangzhi Chen, Xin Song, Lushan Xue, Cheng Zhang, Xuemin Li, Haifeng Zhao
{"title":"患有慢性病及其多病的老年人的炎症性饮食模式与认知障碍风险之间的关系：一项横断面研究","authors":"Lili Wang, Le Cheng, Chenhui Lv, Jie Kou, Wenjuan Feng, Haoran Xie, Ruolin Yan, Xi Wang, Shuangzhi Chen, Xin Song, Lushan Xue, Cheng Zhang, Xuemin Li, Haifeng Zhao","doi":"10.2147/CIA.S474907","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The present study aimed to explore the association between the inflammatory potential of diet, assessed by energy-adjusted dietary inflammatory index (E-DII) and reduced rank regression (RRR)-derived inflammatory dietary pattern, and the risk for cognitive impairment (CI) in community-dwelling older adults, especially in older adults with chronic diseases and multimorbidity.</p><p><strong>Methods: </strong>A total of 549 older adults from Taiyuan city were included in the present cross-sectional study. The Chinese Version of the Mini-Mental State Examination (CMMSE) was used for the evaluation of cognitive function. E-DII score was calculated based on semi-quantitative food frequency questionnaire (FFQ). Blood samples, including interleukin (IL)-1β, interleukin (IL)-18, tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP), were tested for calculating RRR-derived inflammatory dietary pattern. Logistic regression was used to assess the association between inflammatory dietary pattern and risk of CI. In addition, patients with diabetes, hypertension, hyperlipidemia and multimorbidity were screened for further analysis among 549 older adults.</p><p><strong>Results: </strong>In those 549 older adults, adjusting for demographic characteristics and chronic disease status, there was no association between E-DII score tertile (OR <i><sub>T3VST1</sub></i> : 1.357, 95%<i>CI</i>:0.813~2.265, <i>P</i> <sub>trend</sub> = 0.267), RRR-derived inflammatory dietary pattern score tertile (OR <i><sub>T3VST1</sub></i> : 1.092, 95%<i>CI</i>:0.679~ 1.758, <i>P</i> <sub>trend</sub> = 0.737) and risk of CI. However, in older adults with diabetes and multimorbidity, the score tertile of E-DII and RRR-derived inflammatory dietary pattern were positively correlated with risk of CI in a dose-responsive manner (All <i>P</i> <sub>trend</sub> < 0.05). There is insufficient evidence to reach similar conclusion in patients with hypertension and hyperlipidemia (All <i>P</i> <sub>trend</sub> > 0.05).</p><p><strong>Conclusion: </strong>In the present study, pro-inflammatory diet contributed to the increased risk of CI in older adults with diabetes and multimorbidity. These results supplemented vital evidence for the prevention and treatment of CI in older adults with chronic diseases.</p>","PeriodicalId":48841,"journal":{"name":"Clinical Interventions in Aging","volume":null,"pages":null},"PeriodicalIF":3.5000,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484775/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Association Between Inflammatory Dietary Pattern and Risk of Cognitive Impairment Among Older Adults with Chronic Diseases and Its Multimorbidity: A Cross-Sectional Study.\",\"authors\":\"Lili Wang, Le Cheng, Chenhui Lv, Jie Kou, Wenjuan Feng, Haoran Xie, Ruolin Yan, Xi Wang, Shuangzhi Chen, Xin Song, Lushan Xue, Cheng Zhang, Xuemin Li, Haifeng Zhao\",\"doi\":\"10.2147/CIA.S474907\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The present study aimed to explore the association between the inflammatory potential of diet, assessed by energy-adjusted dietary inflammatory index (E-DII) and reduced rank regression (RRR)-derived inflammatory dietary pattern, and the risk for cognitive impairment (CI) in community-dwelling older adults, especially in older adults with chronic diseases and multimorbidity.</p><p><strong>Methods: </strong>A total of 549 older adults from Taiyuan city were included in the present cross-sectional study. The Chinese Version of the Mini-Mental State Examination (CMMSE) was used for the evaluation of cognitive function. E-DII score was calculated based on semi-quantitative food frequency questionnaire (FFQ). Blood samples, including interleukin (IL)-1β, interleukin (IL)-18, tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP), were tested for calculating RRR-derived inflammatory dietary pattern. Logistic regression was used to assess the association between inflammatory dietary pattern and risk of CI. In addition, patients with diabetes, hypertension, hyperlipidemia and multimorbidity were screened for further analysis among 549 older adults.</p><p><strong>Results: </strong>In those 549 older adults, adjusting for demographic characteristics and chronic disease status, there was no association between E-DII score tertile (OR <i><sub>T3VST1</sub></i> : 1.357, 95%<i>CI</i>:0.813~2.265, <i>P</i> <sub>trend</sub> = 0.267), RRR-derived inflammatory dietary pattern score tertile (OR <i><sub>T3VST1</sub></i> : 1.092, 95%<i>CI</i>:0.679~ 1.758, <i>P</i> <sub>trend</sub> = 0.737) and risk of CI. However, in older adults with diabetes and multimorbidity, the score tertile of E-DII and RRR-derived inflammatory dietary pattern were positively correlated with risk of CI in a dose-responsive manner (All <i>P</i> <sub>trend</sub> < 0.05). There is insufficient evidence to reach similar conclusion in patients with hypertension and hyperlipidemia (All <i>P</i> <sub>trend</sub> > 0.05).</p><p><strong>Conclusion: </strong>In the present study, pro-inflammatory diet contributed to the increased risk of CI in older adults with diabetes and multimorbidity. These results supplemented vital evidence for the prevention and treatment of CI in older adults with chronic diseases.</p>\",\"PeriodicalId\":48841,\"journal\":{\"name\":\"Clinical Interventions in Aging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-10-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484775/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Interventions in Aging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/CIA.S474907\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Interventions in Aging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/CIA.S474907","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
研究背景本研究旨在探讨通过能量调整膳食炎症指数（E-DII）和减秩回归（RRR）得出的炎症膳食模式评估的膳食炎症潜力与社区老年人，尤其是患有慢性病和多病的老年人认知障碍（CI）风险之间的关系：本横断面研究共纳入太原市 549 名老年人。方法：本横断面研究共纳入太原市 549 名老年人，采用中国版精神状态小测验（CMMSE）评估认知功能。根据半定量食物频率问卷（FFQ）计算 E-DII 评分。检测血液样本，包括白细胞介素（IL）-1β、白细胞介素（IL）-18、肿瘤坏死因子-α（TNF-α）和C反应蛋白（CRP），以计算RRR衍生的炎症饮食模式。逻辑回归用于评估炎症性饮食模式与 CI 风险之间的关联。此外，还在 549 名老年人中筛选出了糖尿病、高血压、高脂血症和多病患者，以便进行进一步分析：在这549名老年人中，调整人口统计学特征和慢性病状况后，E-DII评分三等分（OR T3VST1：1.357，95%CI：0.813~2.265，P趋势=0.267）、RRR衍生炎症饮食模式评分三等分（OR T3VST1：1.092，95%CI：0.679~1.758，P趋势=0.737）与CI风险之间没有关联。然而，在患有糖尿病和多病的老年人中，E-DII 和 RRR 导出的炎症性饮食模式的三等分与 CI 风险呈剂量反应式的正相关（所有 P 趋势均<0.05）。在高血压和高脂血症患者中，没有足够的证据得出类似的结论（所有 P 趋势均 > 0.05）：在本研究中，促炎性饮食导致患有糖尿病和多病的老年人罹患 CI 的风险增加。这些结果为患有慢性病的老年人预防和治疗 CI 补充了重要证据。
The Association Between Inflammatory Dietary Pattern and Risk of Cognitive Impairment Among Older Adults with Chronic Diseases and Its Multimorbidity: A Cross-Sectional Study.
Background: The present study aimed to explore the association between the inflammatory potential of diet, assessed by energy-adjusted dietary inflammatory index (E-DII) and reduced rank regression (RRR)-derived inflammatory dietary pattern, and the risk for cognitive impairment (CI) in community-dwelling older adults, especially in older adults with chronic diseases and multimorbidity.
Methods: A total of 549 older adults from Taiyuan city were included in the present cross-sectional study. The Chinese Version of the Mini-Mental State Examination (CMMSE) was used for the evaluation of cognitive function. E-DII score was calculated based on semi-quantitative food frequency questionnaire (FFQ). Blood samples, including interleukin (IL)-1β, interleukin (IL)-18, tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP), were tested for calculating RRR-derived inflammatory dietary pattern. Logistic regression was used to assess the association between inflammatory dietary pattern and risk of CI. In addition, patients with diabetes, hypertension, hyperlipidemia and multimorbidity were screened for further analysis among 549 older adults.
Results: In those 549 older adults, adjusting for demographic characteristics and chronic disease status, there was no association between E-DII score tertile (OR T3VST1 : 1.357, 95%CI:0.813~2.265, Ptrend = 0.267), RRR-derived inflammatory dietary pattern score tertile (OR T3VST1 : 1.092, 95%CI:0.679~ 1.758, Ptrend = 0.737) and risk of CI. However, in older adults with diabetes and multimorbidity, the score tertile of E-DII and RRR-derived inflammatory dietary pattern were positively correlated with risk of CI in a dose-responsive manner (All Ptrend < 0.05). There is insufficient evidence to reach similar conclusion in patients with hypertension and hyperlipidemia (All Ptrend > 0.05).
Conclusion: In the present study, pro-inflammatory diet contributed to the increased risk of CI in older adults with diabetes and multimorbidity. These results supplemented vital evidence for the prevention and treatment of CI in older adults with chronic diseases.
期刊介绍：
Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
