抑制性神经元的功能网络协调了海马的同步性。

IF 9.8 1区 生物学 Q1 Agricultural and Biological Sciences PLoS Biology Pub Date : 2024-10-14 eCollection Date: 2024-10-01 DOI:10.1371/journal.pbio.3002837
Marco Bocchio, Artem Vorobyev, Sadra Sadeh, Sophie Brustlein, Robin Dard, Susanne Reichinnek, Valentina Emiliani, Agnes Baude, Claudia Clopath, Rosa Cossart
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引用次数: 0

摘要

抑制性中间神经元是大脑皮层回路的关键组成部分。除了提供抑制作用外,它们还被认为能协调细胞集合内兴奋神经元的发射。虽然对特定中间神经元亚型的作用进行了广泛的研究,但它们对锥体细胞体内同步性的影响仍然难以捉摸。我们在小鼠体内采用全光方法,同时记录海马中间神经元和锥体细胞,并利用光遗传学方法探究单个中间神经元对网络的影响。我们证明,CA1 中间神经元形成了一个功能性互连网络,在保持内源性细胞集结的同时,通过在清醒不动状态下解除抑制来促进同步性。我们的网络模型强调了细胞集结和密集的非特异性中间神经元连接在解释我们的实验发现方面的重要性,表明中间神经元可能不仅通过分工而且还通过协同活动来运作。
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Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus.

Inhibitory interneurons are pivotal components of cortical circuits. Beyond providing inhibition, they have been proposed to coordinate the firing of excitatory neurons within cell assemblies. While the roles of specific interneuron subtypes have been extensively studied, their influence on pyramidal cell synchrony in vivo remains elusive. Employing an all-optical approach in mice, we simultaneously recorded hippocampal interneurons and pyramidal cells and probed the network influence of individual interneurons using optogenetics. We demonstrate that CA1 interneurons form a functionally interconnected network that promotes synchrony through disinhibition during awake immobility, while preserving endogenous cell assemblies. Our network model underscores the importance of both cell assemblies and dense, unspecific interneuron connectivity in explaining our experimental findings, suggesting that interneurons may operate not only via division of labor but also through concerted activity.

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来源期刊
PLoS Biology
PLoS Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOLOGY
CiteScore
15.40
自引率
2.00%
发文量
359
审稿时长
3-8 weeks
期刊介绍: PLOS Biology is the flagship journal of the Public Library of Science (PLOS) and focuses on publishing groundbreaking and relevant research in all areas of biological science. The journal features works at various scales, ranging from molecules to ecosystems, and also encourages interdisciplinary studies. PLOS Biology publishes articles that demonstrate exceptional significance, originality, and relevance, with a high standard of scientific rigor in methodology, reporting, and conclusions. The journal aims to advance science and serve the research community by transforming research communication to align with the research process. It offers evolving article types and policies that empower authors to share the complete story behind their scientific findings with a diverse global audience of researchers, educators, policymakers, patient advocacy groups, and the general public. PLOS Biology, along with other PLOS journals, is widely indexed by major services such as Crossref, Dimensions, DOAJ, Google Scholar, PubMed, PubMed Central, Scopus, and Web of Science. Additionally, PLOS Biology is indexed by various other services including AGRICOLA, Biological Abstracts, BIOSYS Previews, CABI CAB Abstracts, CABI Global Health, CAPES, CAS, CNKI, Embase, Journal Guide, MEDLINE, and Zoological Record, ensuring that the research content is easily accessible and discoverable by a wide range of audiences.
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