正常钙血症原发性甲状旁腺功能亢进与心脏代谢改变无关。

IF 3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Endocrine Pub Date : 2024-12-01 Epub Date: 2024-10-15 DOI:10.1007/s12020-024-04063-0
Marco Barale, Federica Maiorino, Alessia Pusterla, Federica Fraire, Lorenzo Sauro, Michela Presti, Noemi Sagone, Ezio Ghigo, Emanuela Arvat, Massimo Procopio
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引用次数: 0

摘要

目的:心脏代谢紊乱是高钙血症性原发性甲状旁腺功能亢进症(HC-PHPT)的非典型并发症,但这种风险是否意味着正常钙血症性原发性甲状旁腺功能亢进症(NC-PHPT)仍有待阐明。我们研究了这两种形式的PHPT的心脏代谢变化,寻找它们与疾病活动性指数之间的关联:方法:我们在骨代谢疾病门诊转诊中心对HC-PHPT(17例)、NC-PHPT(17例)患者和年龄、性别、体重指数相匹配的对照组(34例)进行了血糖、血脂、血压变化和心血管事件史评估,以开展一项病例对照研究:结果:与对照组相比,NC-PHPT 患者的血糖(平均±标准差,88±11 vs 95±22 mg/dl)、总胆固醇(199±25 vs 207±36 mg/dl)和收缩压水平(SBP,132±23 vs 132±19 mmHg)相似,血糖变化(6% vs 9%)、血脂紊乱(41% vs 50%)和高血压(53% vs 59%,所有比较中 p = NS)的发生频率也相当。相反,所有这些异常在 HC-PHPT 与对照组中的发生率更高(p 结论:NC-PHPT 与血糖变化无关:NC-PHPT与心血管改变无关。高钙血症在心血管代谢紊乱的发展过程中起着主要的致病作用,这可能是 NC-PHPT 中没有此类改变的原因。
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Normocalcemic primary hyperparathyroidism is not associated with cardiometabolic alterations.

Purpose: Cardiometabolic disorders are non-classical complications of hypercalcemic primary hyperparathyroidism (HC-PHPT), but whether this risk connotes normocalcemic PHPT (NC-PHPT) remains to be elucidated. We investigated cardiometabolic alterations in both forms of PHPT, looking for their association with indices of disease activity.

Methods: Patients with HC-PHPT (n = 17), NC-PHPT (n = 17), and controls (n = 34) matched for age, sex, and BMI were assessed for glucose, lipid, blood pressure alterations, and history of cardiovascular events to perform a case-control study at an ambulatory referral center for Bone Metabolism Diseases.

Results: NC-PHPT, in comparison to controls, showed similar glucose (mean ± SD, 88 ± 11 vs 95 ± 22 mg/dl), total cholesterol (199 ± 25 vs 207 ± 36 mg/dl), and systolic blood pressure levels (SBP, 132 ± 23 vs 132 ± 19 mmHg), together with a comparable frequency of glucose alterations (6% vs 9%), lipid disorders (41% vs 50%) and hypertension (53% vs 59%, p = NS for all comparisons). Conversely, all these abnormalities were more prevalent in HC-PHPT vs controls (p < 0.05). When compared to NC-PHPT, HC-PHPT showed higher glucose (113 ± 31 mg/dl), total cholesterol (238 ± 43 mg/dl), and SBP levels (147 ± 15 mmHg) as well as an increased frequency of glucose (41%) and lipid alterations (77%) and a higher number of cardiovascular events (18% vs 0%, p < 0.05 for all comparisons). Among indices of PHPT activity, calcium levels displayed a significant correlation with glucose (R = 0.46) and SBP values (R = 0.60, p < 0.05).

Conclusion: NC-PHPT is not associated with cardiovascular alterations. The predominant pathogenetic role of hypercalcemia in the development of cardiometabolic disorders could account for the absence of such alterations in NC-PHPT.

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来源期刊
Endocrine
Endocrine ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
5.40%
发文量
295
审稿时长
1.5 months
期刊介绍: Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
期刊最新文献
Correction to: Therapeutic patient education and treatment intensification of diabetes and hypertension in subjects with newly diagnosed type 2 diabetes mellitus: a longitudinal study. Correction: Timing of the repeat thyroid fine-needle aspiration biopsy: does early repeat biopsy change the rate of nondiagnostic or atypia of undetermined significance cytology result? Hematological toxicities with Lutathera® for neuroendocrine neoplasms: post-marketing surveillance data from the US-FDA. SGLT2 inhibitors may reduce non-small cell lung cancer and not increase various neoplasms including several skin cancers. Clarification on the role of thyroid scintigraphy in the era of TIRADS: a response to Trimboli et al. (2024).
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