辐照大鼠消化道组织化学变化。

Physiologie (Bucarest) Pub Date : 1987-07-01

P Groza, A Boca, N Gheorghe

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引用次数: 0

摘要

用500 r单剂量照射Wistar大鼠(110 ~ 125 g)，对其舌下腺、胃、小肠和结肠粘膜的糖蛋白(GP)及部分肠道酶:酸性和碱性磷酸酶(ACP、ALP)、亮氨酸氨基肽酶(LAP)、mg依赖性atp酶、nadh -脱氢酶、乳酸脱氢酶(LDH)进行了组织化学研究。照射后，所有这些反应都减弱，在3-5天内达到最大效果。这种损害符合在产生胃肠综合征的这种照射程度后的这段时间内的最大致死率。辅酶羧化酶，一种放射性保护剂，改善了这些关于小肠结构的变化，也改善了舌下腺、胃、小肠和结肠的GP，证明了它的有效性。

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Histochemical changes in the digestive tract in irradiated rats.

Wistar rats (110-125 g) were irradiated with a single dose of 500 R. Histochemical studies were done concerning the glycoproteins (GP) of sublingual glands, gastric, small intestine and colon mucosa, and some intestinal enzymes: acid and alkaline phosphatase (ACP, ALP) leucineaminopeptidase (LAP), Mg-dependent ATP-ase, NADH-diaphorase, lactic dehydrogenase (LDH). After irradiation all these reactions were diminished, with a maximal effect between 3-5 days. This impairment is in accord with the maximal lethality in this interval after such a degree of irradiation that produced the gastrointestinal syndrome. Cocarboxylase, a radioprotector, improved these changes regarding the structures of the small intestine and also the GP of sublingual glands, stomach, small intestine and colon, demonstrating there its efficiency.

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