假脂母细胞性会阴瘤:一种罕见的组织学亚型。

IF 1.1 4区 医学 Q4 DERMATOLOGY American Journal of Dermatopathology Pub Date : 2024-12-01 Epub Date: 2024-10-15 DOI:10.1097/DAD.0000000000002857
Ozlem Erdem, Barbara Corti, Francesco Paolo Salamone, Bianca Maria Piraccini, Cosimo Misciali
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引用次数: 0

摘要

摘要:假性脂母细胞性会阴瘤是会阴外肿瘤的一种非常罕见的变异型,医学文献中仅记载了有限的几例。其最显著的组织病理学特征是存在空泡细胞,与脂肪母细胞非常相似;此外,还存在小的、纺锤形或上皮样的会阴部细胞。在本研究中,我们发现了另一例假脂母细胞性会厌瘤,其主要特征是存在空泡化的 "假脂母细胞"。EMA、Glut-1、claudin-1、IV 型胶原和层粘连蛋白的免疫组化表达以及 S-100 阴性是诊断的关键,以支持会厌起源。对于这些不会复发或转移的良性肿瘤,简单切除是最佳治疗方案。识别这种罕见的肿瘤,将其与许多其他以突出胞浆内空泡为特征的肿瘤区分开来至关重要。
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Pseudolipoblastic Perineuroma: A Rare Histologi̇c Subtype.

Abstract: Pseudolipoblastic perineurioma is a very uncommon variant of extraneural perineurioma, with only a limited number of cases documented in the medical literature. The most remarkable histopathologic characteristic is the existence of vacuolated cells that closely resemble lipoblasts; besides the presence of small, spindle shaped, or epithelioid perineurial cells. In this study, we present another case of pseudolipoblastic perineurioma, predominantly characterized by the presence of vacuolated "pseudolipoblastic" cells. The immunohistochemical expression of EMA, Glut-1, claudin-1, collagen type IV, and laminin as well as S-100 negativity is essential for the diagnosis to support the perineurial origin. Simple excision is the best treatment option for these benign tumors that do not recur or metastasize. It is crucial to recognize this rare entity to differentiate it from many other tumors characterized by prominent intracytoplasmic vacuoles.

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来源期刊
CiteScore
1.80
自引率
9.10%
发文量
453
审稿时长
3 months
期刊介绍: The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians
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