阴茎和阴囊角化病:单机构经验

IF 1.1 4区 医学 Q4 DERMATOLOGY American Journal of Dermatopathology Pub Date : 2024-11-01 Epub Date: 2024-09-17 DOI:10.1097/DAD.0000000000002801
Burak Tekin, Sounak Gupta, Ruifeng Guo, Julia S Lehman, Carilyn N Wieland, Emma F Johnson
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引用次数: 0

摘要

摘要:有关局限于阴茎和阴囊的角化病的数据很少。我们评估了本院在这方面的经验。我们查阅了病理档案库中 2000 年至 2022 年间所有阴茎或阴囊标本,并将其签发为角化病。我们回顾了临床和组织病理学特征,包括每个组织的粟粒状薄片数量和鳞状发育不良情况。研究共纳入九名患者。确诊时的中位年龄为 51 岁。3 名患者存在多个病灶。6 名患者的阴茎完全受累,2 名患者的阴囊完全受累。一名患者的多处病变与卟啉角化病(porokeratosis ptychotropica)一致,从阴囊延伸至臀部和会阴部。临床上,3 名患者出现鳞屑丘疹,1 名患者在活检前被考虑诊断为角化病。从组织病理学角度看,2 名患者在同一部位出现多个粟粒状薄片,1 名患者出现滤泡状粟粒状薄片。只有一名患者出现灶性鳞状细胞发育不良。对 5 名患者进行了随访(中位随访时间:35 个月)。其中 4 名患者的病灶在刮除活检过程中被完全切除。在过去的随访中,没有任何患者出现复发或恶变为鳞状细胞癌的迹象。阴茎和/或阴囊角化病可能难以仅根据临床特征进行诊断,这就强调了组织病理学检查的作用。提高对这种疾病的认识有助于更好地界定其临床病理表现和适当的分类。
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Penile and Scrotal Porokeratosis: A Single-Institution Experience.

Abstract: There is a paucity of data regarding porokeratosis confined to the penis and scrotum. We evaluated our single-institutional experience regarding this entity. We interrogated our pathology archive for all specimens from the penis or scrotum, signed out as porokeratosis between 2000 and 2022. Clinical and histopathological features were reviewed, including the number of cornoid lamella(e) per tissue profile and squamous dysplasia. Nine patients were included in the study. The median age at the time of diagnosis was 51 years. Multiple lesions were present in 3 patients. Six patients had exclusively penile involvement, whereas 2 patients had exclusively scrotal involvement. One patient had multiple lesions consistent with porokeratosis ptychotropica, extending from the scrotum to the buttocks and perineum. Clinically, a collarette of scale was noted in 3 patients and diagnosis of porokeratosis was considered in 1 patient before biopsy. Histopathologically, 2 patients exhibited multiple cornoid lamellae in the same profile and 1 patient had follicular cornoid lamellae. Focal squamous dysplasia was only present in 1 patient. Follow-up was available for 5 patients (median duration: 35 months). In 4 patients, the lesions were removed completely during the shave biopsy procedure. At the past follow-up, there were no signs of recurrence or malignant transformation to squamous cell carcinoma in any patient. Porokeratosis involving the penis and/or scrotum may be elusive to diagnosis based on clinical features alone, emphasizing the role of histopathological examination. Increased awareness of this entity may help better delineate its clinicopathological presentation and appropriate classification.

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来源期刊
CiteScore
1.80
自引率
9.10%
发文量
453
审稿时长
3 months
期刊介绍: The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians
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