基于酰胺质子转移成像和弥散加权成像预测鼻咽癌新辅助化疗早期疗效的价值

IF 2.9 2区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Quantitative Imaging in Medicine and Surgery Pub Date : 2024-10-01 Epub Date: 2024-09-26 DOI:10.21037/qims-24-188
Yulin Zhang, Guomin Li, Jinyan Chen, Meien Jiang, Yunyu Gao, Kunsong Li, Hua Wen, Jianhao Yan
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引用次数: 0

摘要

背景:早期发现对新辅助化疗(NAC)不敏感的鼻咽癌(NPC)患者可避免过度治疗。本研究旨在评估酰胺质子转移成像(APT)和弥散加权成像(DWI)在预测鼻咽癌患者对新辅助化疗早期反应方面的有效性:这项前瞻性研究在2021年9月至2023年5月期间招募了50名经活检确诊的鼻咽癌患者。在接受新农合治疗前进行磁共振成像(MRI),包括 APT 和 DWI。NAC后,根据实体瘤反应评估标准1.1版将患者分为完全反应组(CR)、部分反应组(PR)、疾病稳定组(SD)和疾病进展组(PD)。统计分析采用 Kruskal-Wallis H 检验。比较不同疗效组间 APT 和表观弥散系数(ADC)值的差异,绘制具有统计学意义参数的接收者操作特征曲线(ROC),并计算曲线下面积(AUC):50 名患者(平均年龄:47±14 岁;男性 42 人,女性 8 人)被纳入最终分析(CR 组 11 人,PR 组 30 人,SD 组 9 人,PD 组 0 人)。不同治疗反应组的 ADC 值无明显差异。SD 组的 APTmax(P=0.025)、APTskewness(P=0.025)和 APT90% (P=0.001)值明显低于 CR 组和 PR 组。以 APT90% =3.10% 为临界值,在预测 SD 组时可获得最佳诊断效果(AUC:0.831;灵敏度:0.778;特异性:0.878):结论:APT成像可预测鼻咽癌患者对NAC的早期肿瘤反应。在预测肿瘤反应方面,APT成像可能优于DWI成像。
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The value of predicting neoadjuvant chemotherapy early efficacy in nasopharyngeal carcinoma based on amide proton transfer imaging and diffusion weighted imaging.

Background: Early detection of nasopharyngeal carcinoma (NPC) patients who are not sensitive to neoadjuvant chemotherapy (NAC) can guard against overtreatment. This study aimed to evaluate the effectiveness of amide proton transfer (APT) imaging and diffusion-weighted imaging (DWI) in predicting the early response to NAC in patients with NPC.

Methods: This prospective study enrolled fifty patients with biopsy-confirmed NPC from September 2021 to May 2023. Magnetic resonance imaging (MRI) including APT and DWI, was performed before NAC. After NAC, patients were divided into complete response (CR), partial response (PR), and stable disease (SD) and progressive disease (PD) groups based on the Response Evaluation Criteria in Solid Tumours Version 1.1. The Kruskal-Wallis H test was used for statistical analysis. The differences in APT and apparent diffusion coefficient (ADC) values among the different efficacy groups were compared, the receiver operating characteristic (ROC) curve was drawn for statistically significant parameters, and the area under the curve (AUC) was calculated.

Results: Fifty patients (mean age: 47±14 years; 42 males and 8 females) were included in the final analysis (11 were in the CR group, 30 in the PR group, 9 in the SD group, and 0 in the PD group). The ADC values showed no significant differences among the different treatment response groups. The SD group showed significantly lower APTmax (P=0.025), APTskewness (P=0.025) and APT90% (P=0.001) values than the CR and PR groups. Setting APT90% =3.10% as the cut-off value, optimal diagnostic performance (AUC: 0.831; sensitivity: 0.778; specificity: 0.878) was obtained in predicting the SD group.

Conclusions: APT imaging can predict the early tumour response to NAC in patients with NPC. APT imaging may be superior to DWI in predicting tumour response.

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Quantitative Imaging in Medicine and Surgery
Quantitative Imaging in Medicine and Surgery Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
4.20
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17.90%
发文量
252
期刊介绍: Information not localized
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