头颈癌中的非编码 RNA 和耐药性。

IF 4.6 Q1 ONCOLOGY 癌症耐药(英文) Pub Date : 2024-09-20 eCollection Date: 2024-01-01 DOI:10.20517/cdr.2024.59
Yulong Zhang, Yingming Peng, Bingqin Lin, Shuai Yang, Feiqiang Deng, Xuan Yang, An Li, Wanyi Xia, Chenxi Gao, Shaona Lei, Wei Liao, Qi Zeng
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引用次数: 0

摘要

头颈癌(HNC)被列为第六大常见恶性肿瘤,目前的治疗方案的总体生存率仍然令人担忧,这主要是由于抗肿瘤治疗后产生的耐药性。最近的研究表明,非编码 RNA 在 HNC 患者的耐药性中起着至关重要的作用。本文系统回顾了当前的研究现状,探讨了与非编码 RNA 和 HNC 耐药性相关的新靶点和治疗策略,提出了一些尚未解决的问题,并讨论了该领域五个前景广阔的研究方向:铁肽化、纳米药物、外泌体、蛋白酶靶向嵌合体 (PROTAC) 和人工智能。我们希望我们的工作将有助于推动通过调控非编码 RNA 克服 HNC 抗性的研究。
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Non-coding RNA and drug resistance in head and neck cancer.

Head and neck cancer (HNC) is ranked as the sixth most common malignant tumor, and the overall survival rate with current treatment options remains concerning, primarily due to drug resistance that develops following antitumor therapy. Recent studies indicate that non-coding RNAs play a crucial role in drug resistance among HNC patients. This article systematically reviews the current research landscape, explores novel targets and treatment strategies related to non-coding RNAs and HNC resistance, raises some unresolved issues, and discusses five promising research directions in this field: ferroptosis, nanomedicine, exosomes, proteolysis-targeting chimeras (PROTACs), and artificial intelligence. We hope that our work will contribute to advancing research on overcoming HNC resistance through the regulation of non-coding RNAs.

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