兔模型鼻骨切开术的组织病理学比较分析

Deniz Hanci, Berk Gurpinar, Huseyin Altun, Oyku Izel Onaran, Ugur Uygan, Omer Kumas, Yavuz Uyar
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摘要

目的:鼻骨截骨术是鼻整形术中的一个关键步骤,可明确解决鼻骨的开顶畸形问题。本研究旨在兔模型中评估和比较与 4 种不同截骨技术相关的恢复模式。材料和方法:研究对象包括 20 只体重为 2.5 至 3.0 千克的白色新西兰兔。在左侧使用压刀进行正中截骨,在右侧使用摆动微锯进行正中截骨。此外,所有兔子都使用凿子进行了右侧内截骨术和左侧外截骨术。第 7 天宰杀 10 只兔子,第 15 天宰杀其余 10 只兔子,进行组织学检查。通过苏木精、伊红和马森三色染色切片对肉芽组织形成(GTF)、血管形成、炎症、胶原纤维含量、截骨间隙宽度和新骨形成进行评估。结果第 7 天,与摆动式微锯相比,压电手术在 GTF、新生血管和胶原纤维数量方面具有显著的统计学优势(P < .05)。此外,在第 7 天和第 15 天之间,观察到各组之间在结缔组织组织分布方面存在显著统计学差异(P < .05)。结论:本研究结果明确证实,在该兔子模型中,使用压电手术进行截骨后的骨愈合效果优于使用摆动微锯。
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Comparative Histopathological Analysis of Nasal Osteotomy Techniques in a Rabbit Model.

Objective: Nasal osteotomy is a crucial step in rhinoplasty, explicitly addressing the open roof deformity in nasal bones. This study aimed to assess and compare the recovery patterns associated with 4 distinct osteotomy techniques in a rabbit model. Materials and Methods: Twenty white New Zealand rabbits weighing 2.5 to 3.0 kg were included in the study. Median osteotomies were performed on the left side using piezosurgery and on the right side using an oscillating micro-saw. Additionally, internal osteotomy was executed on the right side and external osteotomy on the left side, both performed with a chisel across all rabbits. Ten rabbits were sacrificed on the 7th day, while the remaining 10 were sacrificed on the 15th day for subsequent histological examination. The granulation tissue formation (GTF), vascularization, inflammation, collagen fibril content, osteotomy gap width, and new bone formation were evaluated in hematoxylin and eosin and Masson's trichrome-stained sections. Results: On the 7th day, piezosurgery demonstrated statistically-significant advantages in terms of GTF, neovascularization, and collagen fibril quantity when compared to the oscillating micro-saw (P < .05). Furthermore, a statistically-significant difference was observed among the groups concerning the distribution of connective tissue organization between the 7th and 15th days (P < .05). Conclusions: This study's findings unequivocally establish that bone healing after osteotomy with piezosurgery surpasses that achieved with an oscillating micro-saw in this rabbit model.

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