NIAGADS:阿尔茨海默病及相关痴呆症遗传学和基因组学研究国家综合数据库。

Amanda Kuzma, Otto Valladares, Emily Greenfest-Allen, Heather Nicaretta, Maureen Kirsch, Youli Ren, Zivadin Katanic, Heather White, Andrew Wilk, Lauren Bass, Jascha Brettschneider, Luke Carter, Jeffrey Cifello, Wei-Hsuan Chuang, Kaylyn Clark, Prabhakaran Gangadharan, Jacob Haut, Pei-Chuan Ho, Wenhwai Horng, Taha Iqbal, Yumi Jin, Peter Keskinen, Alexis Lerro Rose, Michelle K Moon, Joseph Manuel, Liming Qu, Flawless Robbins, Naveensri Saravanan, Jin Sha, Sam Tate, Yi Zhao, Laura Cantwell, Jake Gardner, Shin-Yi Chou, Jung-Ying Tzeng, William Bush, Adam Naj, Pavel Kuksa, Wan-Ping Lee, Yuk Yee Leung, Gerard Schellenberg, Li-San Wang
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摘要

NIAGADS 是美国国家老龄化研究所 (NIA) 指定的阿尔茨海默病及相关痴呆症 (ADRD) 人类遗传学研究国家数据存储库。NIAGADS 为 ADRD 遗传学/基因组研究维护高质量的数据收集,并支持遗传学数据的生产和分析。NIAGADS 拥有来自阿尔茨海默病测序项目 (ADSP) 的全基因组和外显子组序列数据以及其他基因型/表型数据,涵盖 209,000 个样本。NIAGADS 通过 "数据共享服务 "与全球数百个研究小组共享这些数据。"数据共享服务 "是一个符合 FISMA 标准的云平台,完全支持 NIH 基因组数据共享政策。NIAGADS Open Access 包含多个知识库,其中有全基因组关联汇总统计数据,以及关于人类基因组中遗传变异和基因的生物学意义的丰富注释。NIAGADS 是促进合作,推动对阿尔茨海默病的了解和治疗的基石。
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NIAGADS: A Comprehensive National Data Repository for Alzheimer's Disease and Related Dementia Genetics and Genomics Research.

NIAGADS is the National Institute on Aging (NIA) designated national data repository for human genetics research on Alzheimer's Disease and related dementia (ADRD). NIAGADS maintains a high-quality data collection for ADRD genetic/genomic research and supports genetics data production and analysis. NIAGADS hosts whole genome and exome sequence data from the Alzheimer's Disease Sequencing Project (ADSP) and other genotype/phenotype data, encompassing 209,000 samples. NIAGADS shares these data with hundreds of research groups around the world via the Data Sharing Service, a FISMA moderate compliant cloud-based platform that fully supports the NIH Genome Data Sharing Policy. NIAGADS Open Access consists of multiple knowledge bases with genome-wide association summary statistics and rich annotations on the biological significance of genetic variants and genes across the human genome. NIAGADS stands as a keystone in promoting collaborations to advance the understanding and treatment of Alzheimer's disease.

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