更正:"作为抗肿瘤药物的吡喃咔唑新型一氧化氮释放衍生物:设计、合成、生物学评价和一氧化氮释放研究" [Eur. J. Med. Chem. 244 (2022) 114832 / EJMECH-D-22-01635R2] 的更正

IF 5.9 2区 医学 Q1 CHEMISTRY, MEDICINAL European Journal of Medicinal Chemistry Pub Date : 2024-12-15 Epub Date: 2024-10-22 DOI:10.1016/j.ejmech.2024.116957
Yingda Zang , Lei Huang , Xinyi Chen , Chuangjun Li, Jie Ma, Xiaoguang Chen, Dongming Zhang, Fangfang Lai
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引用次数: 0

摘要

由于作者在制作本文图表时的疏忽,图 4 中出现了错误,作者对此表示遗憾。菌落形成检测作为金标准,一般用于调节细胞毒性药物对体外癌细胞增殖的长期影响。本实验使用 MDA-MB-231 细胞来评估化合物对细胞集落形成的影响。如图 4 所示,化合物 7a 从 0.25 μM 浓度开始以剂量依赖的方式抑制细胞集落的形成,其效果强于阳性对照化合物 CZN-13。CZN13 只有在浓度为 5 μM 时才开始明显抑制细胞集落的形成。结果表明,7a 能抑制癌细胞增殖。浓度为 0.25 μM 7a 和 5 μM CZN-13 的克隆图像中没有细胞。因此,这两张图片看起来几乎一样。笔者在拼图时不小心粘贴了相同的图像。在此更正 5 μM 时的 CZN-13 图像:下载高清图片 (531KB)Download:下载全尺寸图片
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Corrigendum to “Novel Nitric oxide-releasing derivatives of pyranocarbazole as antitumor agents: Design, synthesis, biological evaluation, and nitric oxide release studies” [Eur. J. Med. Chem. 244 (2022) 114832 / EJMECH-D-22-01635R2]
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来源期刊
CiteScore
11.70
自引率
9.00%
发文量
863
审稿时长
29 days
期刊介绍: The European Journal of Medicinal Chemistry is a global journal that publishes studies on all aspects of medicinal chemistry. It provides a medium for publication of original papers and also welcomes critical review papers. A typical paper would report on the organic synthesis, characterization and pharmacological evaluation of compounds. Other topics of interest are drug design, QSAR, molecular modeling, drug-receptor interactions, molecular aspects of drug metabolism, prodrug synthesis and drug targeting. The journal expects manuscripts to present the rational for a study, provide insight into the design of compounds or understanding of mechanism, or clarify the targets.
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