Corrigendum to “Novel Nitric oxide-releasing derivatives of pyranocarbazole as antitumor agents: Design, synthesis, biological evaluation, and nitric oxide release studies” [Eur. J. Med. Chem. 244 (2022) 114832 / EJMECH-D-22-01635R2]

The authors regret < that there was an error in Fig. 4, owing to the negligence of the authors when generating the figures of this paper. Colony formation assay, the gold standard, is generally used to regulate the long-term effects of cytotoxic agents on the proliferation of cancer cells in vitro. In this experiment, MDA-MB-231 cells were used to evaluate the effect of compounds on cell colony formation. As shown in Fig. 4, compound 7a could inhibit cell colony formation in a dose-dependent manner starting from a concentration of 0.25 μM, with a stronger effect than the positive control compound CZN-13. CZN13 began to significantly inhibit cell colony formation only at a concentration of 5 μM. The results suggest that 7a inhibits cancer cell proliferation. There were no cells in the clone images at concentrations of 0.25 μM 7a and 5 μM CZN-13. So the two images look almost the same. The author accidently pasted the same image when during figure combining process. Hereby corrects the image of CZN-13 at 5 μM.

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