尿液中的中性粒细胞和 UMOD 捕集器捕获的细菌

IF 28.6 1区医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Nephrology Pub Date : 2024-10-22 DOI:10.1038/s41581-024-00903-4

Monica Wang

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引用次数: 0

摘要

有几种机制可以防止尿路致病菌从膀胱上升到肾脏，从而导致肾盂肾炎。Menna Clatworthy 及其同事的一项新研究阐明了中性粒细胞胞外捕获器（NET）在这一保护机制中的作用。研究人员注意到，在白细胞酯酶尿液浸量棒检测呈阴性的人的尿液中存在中性粒细胞（该检测通常被认为能检测出尿液中的中性粒细胞，作为尿路感染的标志物），研究人员还证明，只有当存在NET化的中性粒细胞而非完整的中性粒细胞时，该检测才呈阳性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bacteria caught in neutrophil and UMOD traps in urine

Several mechanisms prevent the ascent of uropathogenic bacteria from the bladder to the kidney, which can lead to pyelonephritis. A new study by Menna Clatworthy and colleagues clarifies the role of neutrophil extracellular traps (NETs) in this protection.

Noting the presence of neutrophils in urine from individuals with a negative leukocyte esterase urine dipstick test (which is typically thought to detect neutrophils in urine as a UTI marker), the researchers also demonstrated that the test was positive only in the presence of NETosing, and not intact, neutrophils.

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来源期刊

Nature Reviews Nephrology 医学-泌尿学与肾脏学

CiteScore

39.00

自引率

1.20%

发文量

127

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.

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