通过靶向 T 细胞反应治疗 AAV

IF 28.6 1区 医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Nephrology Pub Date : 2024-10-22 DOI:10.1038/s41581-024-00904-3
Monica Wang
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引用次数: 0

摘要

目前,糖皮质激素被用于诱导抗中性粒细胞胞浆抗体肾小球肾炎(ANCA-GN)患者病情缓解,但这些药物具有很高的不良反应和感染风险。Christian Krebs、Ulf Panzer及其同事的一项新研究发现,通过抑制细胞因子来靶向T细胞可能是另一种治疗方法。通过数字药理学分析发现,靶向IL-12和IL-23的单克隆抗体乌斯特库单抗(ustekinumab)是靶向TH1和TH17细胞的候选疗法。使用流式细胞术确认了这些T细胞亚群在另一批ANCA-GN患者的肾脏炎症区域富集。在这批患者中,有四名复发患者在接受标准疗法环磷酰胺和类固醇治疗的同时,还接受了乌司替尼治疗。治疗26周后,患者的临床和血清学反应均呈阳性,且未出现严重不良反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Treating AAV by targeting T cell responses
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来源期刊
Nature Reviews Nephrology
Nature Reviews Nephrology 医学-泌尿学与肾脏学
CiteScore
39.00
自引率
1.20%
发文量
127
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.
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