EviPrompt: A Training-Free Evidential Prompt Generation Method for Adapting Segment Anything Model in Medical Images

Medical image segmentation is a critical task in clinical applications. Recently, the Segment Anything Model (SAM) has demonstrated potential for natural image segmentation. However, the requirement for expert labour to provide prompts, and the domain gap between natural and medical images pose significant obstacles in adapting SAM to medical images. To overcome these challenges, this paper introduces a novel prompt generation method named EviPrompt. The proposed method requires only a single reference image-annotation pair, making it a training-free solution that significantly reduces the need for extensive labelling and computational resources. First, prompts are automatically generated based on the similarity between features of the reference and target images, and evidential learning is introduced to improve reliability. Then, to mitigate the impact of the domain gap, committee voting and inference-guided in-context learning are employed, generating prompts primarily based on human prior knowledge and reducing reliance on extracted semantic information. EviPrompt represents an efficient and robust approach to medical image segmentation. We evaluate it across a broad range of tasks and modalities, confirming its efficacy. The source code is available at https://github.com/SPIresearch/EviPrompt .