抑制 mtDNA 转录本翻译可改变阿尔茨海默病相关生物学特性

IF 13 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2024-10-23 DOI:10.1002/alz.14275

Alexander P. Gabrielli, Lesya Novikova, Amol Ranjan, Xiaowan Wang, Nicholas J. Ernst, Dhanushki Abeykoon, Anysja Roberts, Annie Kopp, Clayton Mansel, Linlan Qiao, Colton R. Lysaker, Ian W. Wiedling, Heather M. Wilkins, Russell H. Swerdlow

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引用次数: 0

摘要

阿尔茨海默病（AD）的特征是线粒体结构和功能发生变化。研究人员就线粒体病理学在其他阿尔茨海默病特征的时间和背景中的定位展开了争论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Inhibiting mtDNA transcript translation alters Alzheimer's disease-associated biology

Alzheimer's disease (AD) features changes in mitochondrial structure and function. Investigators debate where to position mitochondrial pathology within the chronology and context of other AD features.

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.