Caroline Stanton, Kayla Nutsch, Michael J. Bollong
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Covalent modification of cysteine by electrophilic small molecules enables broad targeting of the unliganded proteome. A study reveals that cysteine reactive electrophiles can induce widespread degradation of host proteins and remodeling of cellular proteostasis at commonly used concentrations.
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Nature Chemical Biology stands as an esteemed international monthly journal, offering a prominent platform for the chemical biology community to showcase top-tier original research and commentary. Operating at the crossroads of chemistry, biology, and related disciplines, chemical biology utilizes scientific ideas and approaches to comprehend and manipulate biological systems with molecular precision.
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