从工作台到床边的 GDF15 研究

IF 48.8 1区医学 Q1 CELL BIOLOGY Cancer Cell Pub Date : 2024-10-24 DOI:10.1016/j.ccell.2024.10.002

Samuel N. Breit, David A. Brown, Vicky W.W. Tsai

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引用次数: 0

摘要

临床前数据表明，循环生长分化因子 15（GDF15）的增加是导致厌食/腹痛综合征和妊娠剧吐的原因之一，这些严重的疾病目前尚无非常有效的治疗方法。新英格兰医学杂志》对一种治疗性 GDF15 单克隆抗体进行的二期研究表明，有效治疗癌症厌食症/腹痛症的方法可能即将问世。

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GDF15 research from bench to bedside

Pre-clinical data suggest that increased circulating growth differentiation factor 15 (GDF15) is a cause of both anorexia/cachexia syndromes and hyperemesis gravidarum in pregnancy, serious conditions with no highly effective treatment. A phase 2 study of a therapeutic GDF15 monoclonal antibody in the New England Journal of Medicine suggests that effective treatment of anorexia/cachexia in cancer may be approaching.

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.