2018-2024 年刚果民主共和国 I 支 mpox 病毒基因组多样性：人畜共患病传播占主导地位

IF 5.7 1区化学 Q2 CHEMISTRY, PHYSICAL Journal of Chemical Theory and Computation Pub Date : 2024-10-24 DOI:10.1016/j.cell.2024.10.017

Eddy Kinganda-Lusamaki, Adrienne Amuri-Aziza, Nicolas Fernandez-Nuñez, Jean-Claude Makangara-Cigolo, Catherine Pratt, Emmanuel Hasivirwe Vakaniaki, Nicole A. Hoff, Gradi Luakanda-Ndelemo, Prince Akil-Bandali, Sabin Sabiti Nundu, Noella Mulopo-Mukanya, Michel Ngimba, Brigitte Modadra-Madakpa, Ruth Diavita, Princesse Paku-Tshambu, Elisabeth Pukuta-Simbu, Sydney Merritt, Áine O’Toole, Nicola Low, Antoine Nkuba-Ndaye, Steve Ahuka-Mundeke

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引用次数: 0

摘要

最近的报道引起了人们对刚果民主共和国（DRC）麻风腮流行病学变化的关注。我们为来自14/26个省的337名患者生成了高质量的基因组，以记录病例数的增加是由于人畜共患病的蔓延还是病毒的进化，其中APOBEC3突变的富集与人类的适应有关。我们的研究强调了导致人类病例来源的两种传播模式。来自南基伍省东部的所有新序列（n = 17；4.8%）都与最近描述的支系 Ib 相符，这与性接触和持续的人际传播有关。与此相反，所有其他基因组都属于Ia支系，与Ib支系相比，Ia支系表现出较高的遗传多样性，但APOBEC3变异的数量较少，这表明存在多次人畜共患病的传入。在城市地区出现多个 I 支系变异体突出表明，需要协调国际应对努力，并对 mpox 的传播和储存库进行更多研究。

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Clade I mpox virus genomic diversity in the Democratic Republic of the Congo, 2018–2024: Predominance of zoonotic transmission

Recent reports raise concerns on the changing epidemiology of mpox in the Democratic Republic of the Congo (DRC). High-quality genomes were generated for 337 patients from 14/26 provinces to document whether the increase in number of cases is due to zoonotic spillover events or viral evolution, with enrichment of APOBEC3 mutations linked to human adaptation. Our study highlights two patterns of transmission contributing to the source of human cases. All new sequences from the eastern South Kivu province (n = 17; 4.8%) corresponded to the recently described clade Ib, associated with sexual contact and sustained human-to-human transmission. By contrast, all other genomes are clade Ia, which exhibits high genetic diversity with low numbers of APOBEC3 mutations compared with clade Ib, suggesting multiple zoonotic introductions. The presence of multiple clade I variants in urban areas highlights the need for coordinated international response efforts and more studies on the transmission and the reservoir of mpox.

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来源期刊

Journal of Chemical Theory and Computation 化学-物理：原子、分子和化学物理

CiteScore

9.90

自引率

16.40%

发文量

568

审稿时长

1 months

期刊介绍： The Journal of Chemical Theory and Computation invites new and original contributions with the understanding that, if accepted, they will not be published elsewhere. Papers reporting new theories, methodology, and/or important applications in quantum electronic structure, molecular dynamics, and statistical mechanics are appropriate for submission to this Journal. Specific topics include advances in or applications of ab initio quantum mechanics, density functional theory, design and properties of new materials, surface science, Monte Carlo simulations, solvation models, QM/MM calculations, biomolecular structure prediction, and molecular dynamics in the broadest sense including gas-phase dynamics, ab initio dynamics, biomolecular dynamics, and protein folding. The Journal does not consider papers that are straightforward applications of known methods including DFT and molecular dynamics. The Journal favors submissions that include advances in theory or methodology with applications to compelling problems.