迷走神经刺激治疗帕金森病:动物研究和人体研究范围综述

IF 6.7 1区 医学 Q1 NEUROSCIENCES NPJ Parkinson's Disease Pub Date : 2024-10-24 DOI:10.1038/s41531-024-00803-1
Alexandra Evancho, Melissa Do, Damiana Fortenberry, Rebecca Billings, Alibek Sartayev, William J. Tyler
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引用次数: 0

摘要

帕金森病(Parkinson's Disease,PD)是一种常见的进行性神经退行性疾病,伴有运动和非运动症状。迷走神经刺激(VNS)已成为治疗帕金森病的一种潜在方法,但已发表的相关研究结果却大相径庭。这篇范围界定综述描绘了有关 VNS 治疗帕金森病的现有文献,重点介绍了刺激方法、操作参数、安全性概况、神经生理学机制以及人类和动物模型的临床结果。通过在线数据库,我们找到了 2013 年至 2023 年间发表的 788 篇论文,并从中筛选出 17 篇关于有创和无创 VNS 治疗帕金森病的文献。研究显示,VNS参数和研究设计存在很大差异。动物模型和人类受试者的证据表明,VNS 对帕金森病相关病理和运动功能改善具有潜在的神经生理效应。然而,文献中仍存在很大的空白。未来的研究应包括研究设计的严格报告、刺激参数的标准化和更大的样本量,以最终促进 VNS 转化为临床实践。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Vagus nerve stimulation in Parkinson’s disease: a scoping review of animal studies and human subjects research

Parkinson’s Disease (PD) is a prevalent, progressive neurodegenerative disease with motor and non-motor symptoms. Vagus Nerve Stimulation (VNS) has emerged as a potential therapeutic approach for PD, but published research on this topic varies widely. This scoping review maps existing literature on VNS for PD, highlighting stimulation methods, operational parameters, safety profiles, neurophysiological mechanisms, and clinical outcomes in human and animal models. Online databases were used to identify 788 papers published between 2013 and 2023, from which 17 publications on invasive and non-invasive VNS in PD were selected. Studies showed high variability in VNS parameters and study design. Evidence in animal models and human subjects suggests potential neurophysiological effects on PD-related pathology and motor function improvements. However, significant gaps in the literature remain. Future research should include rigorous reporting of study design, standardization of stimulation parameters, and larger sample sizes to ultimately facilitate translation of VNS into clinical practice.

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来源期刊
NPJ Parkinson's Disease
NPJ Parkinson's Disease Medicine-Neurology (clinical)
CiteScore
9.80
自引率
5.70%
发文量
156
审稿时长
11 weeks
期刊介绍: npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.
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