Aaron M Williams,Ranganath G Kathawate,Ramak Khosravi,Soraya Voigt,John C Haney
{"title":"利用近期出现大面积肺栓塞和慢性血栓栓塞性疾病的肺捐献者进行移植。","authors":"Aaron M Williams,Ranganath G Kathawate,Ramak Khosravi,Soraya Voigt,John C Haney","doi":"10.1016/j.ajt.2024.10.013","DOIUrl":null,"url":null,"abstract":"Organ availability remains a persistent problem in lung transplantation. The use of organs from donors with chronic thromboembolic disease has not been described. In this report, we discuss 2 lung transplant recipients who received organs from donors with acute bilateral pulmonary embolism. All organs underwent backtable pulmonary thromboendarterectomy (PTE) prior to implantation and notably showed evidence of chronic thromboembolic disease and subacute changes in the distal vasculature. Grafts were placed with both patients on veno-arterial (VA) extra-corporeal membrane oxygenation (ECMO). Both patients had unremarkable hospital courses with graft dysfunction scores of 0 at 48 and 72 hours. At follow-up, both patients remained free of graft rejection. We highlight the utility of lungs derived from chronic thromboembolic disease as a strategy to expand the organ pool.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":null,"pages":null},"PeriodicalIF":8.9000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Utilizing Lung Donors with Recent Massive Pulmonary Emboli and Chronic Thromboembolic Disease For Transplantation.\",\"authors\":\"Aaron M Williams,Ranganath G Kathawate,Ramak Khosravi,Soraya Voigt,John C Haney\",\"doi\":\"10.1016/j.ajt.2024.10.013\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Organ availability remains a persistent problem in lung transplantation. The use of organs from donors with chronic thromboembolic disease has not been described. In this report, we discuss 2 lung transplant recipients who received organs from donors with acute bilateral pulmonary embolism. All organs underwent backtable pulmonary thromboendarterectomy (PTE) prior to implantation and notably showed evidence of chronic thromboembolic disease and subacute changes in the distal vasculature. Grafts were placed with both patients on veno-arterial (VA) extra-corporeal membrane oxygenation (ECMO). Both patients had unremarkable hospital courses with graft dysfunction scores of 0 at 48 and 72 hours. At follow-up, both patients remained free of graft rejection. We highlight the utility of lungs derived from chronic thromboembolic disease as a strategy to expand the organ pool.\",\"PeriodicalId\":123,\"journal\":{\"name\":\"American Journal of Transplantation\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":8.9000,\"publicationDate\":\"2024-10-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Transplantation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ajt.2024.10.013\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Transplantation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ajt.2024.10.013","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SURGERY","Score":null,"Total":0}
Utilizing Lung Donors with Recent Massive Pulmonary Emboli and Chronic Thromboembolic Disease For Transplantation.
Organ availability remains a persistent problem in lung transplantation. The use of organs from donors with chronic thromboembolic disease has not been described. In this report, we discuss 2 lung transplant recipients who received organs from donors with acute bilateral pulmonary embolism. All organs underwent backtable pulmonary thromboendarterectomy (PTE) prior to implantation and notably showed evidence of chronic thromboembolic disease and subacute changes in the distal vasculature. Grafts were placed with both patients on veno-arterial (VA) extra-corporeal membrane oxygenation (ECMO). Both patients had unremarkable hospital courses with graft dysfunction scores of 0 at 48 and 72 hours. At follow-up, both patients remained free of graft rejection. We highlight the utility of lungs derived from chronic thromboembolic disease as a strategy to expand the organ pool.
期刊介绍:
The American Journal of Transplantation is a leading journal in the field of transplantation. It serves as a forum for debate and reassessment, an agent of change, and a major platform for promoting understanding, improving results, and advancing science. Published monthly, it provides an essential resource for researchers and clinicians worldwide.
The journal publishes original articles, case reports, invited reviews, letters to the editor, critical reviews, news features, consensus documents, and guidelines over 12 issues a year. It covers all major subject areas in transplantation, including thoracic (heart, lung), abdominal (kidney, liver, pancreas, islets), tissue and stem cell transplantation, organ and tissue donation and preservation, tissue injury, repair, inflammation, and aging, histocompatibility, drugs and pharmacology, graft survival, and prevention of graft dysfunction and failure. It also explores ethical and social issues in the field.