{"title":"钯催化的α、β-不饱和 N-对甲苯磺酰肼与碘醛的级联环化反应：获得 2H-苯并吡喃和 2H-喹啉。","authors":"Yiyi Zheng, Xi-Wei Zhu, Yi-Yun Pan, Fei Sun, Long Yao, Xin-Xing Wu","doi":"10.1039/d4ob01300j","DOIUrl":null,"url":null,"abstract":"<p><p>A palladium-catalyzed cascade reaction of α,β-unsaturated <i>N</i>-tosylhydrazones with iodoarene derivatives containing a nucleophilic group has been developed, which provides facile access to 2<i>H</i>-chromenes and 2<i>H</i>-quinolines, respectively. Additionally, the double Pd-carbene migratory insertion/nucleophilic substitution processes for the synthesis of a ternary heterocyclic skeleton were possible in the developed catalytic system.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Palladium-catalyzed cascade cyclization of α,β-unsaturated <i>N</i>-tosylhydrazones with iodoarenes: access to 2<i>H</i>-chromenes and 2<i>H</i>-quinolines.\",\"authors\":\"Yiyi Zheng, Xi-Wei Zhu, Yi-Yun Pan, Fei Sun, Long Yao, Xin-Xing Wu\",\"doi\":\"10.1039/d4ob01300j\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A palladium-catalyzed cascade reaction of α,β-unsaturated <i>N</i>-tosylhydrazones with iodoarene derivatives containing a nucleophilic group has been developed, which provides facile access to 2<i>H</i>-chromenes and 2<i>H</i>-quinolines, respectively. Additionally, the double Pd-carbene migratory insertion/nucleophilic substitution processes for the synthesis of a ternary heterocyclic skeleton were possible in the developed catalytic system.</p>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-10-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1039/d4ob01300j\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4ob01300j","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Palladium-catalyzed cascade cyclization of α,β-unsaturated N-tosylhydrazones with iodoarenes: access to 2H-chromenes and 2H-quinolines.
A palladium-catalyzed cascade reaction of α,β-unsaturated N-tosylhydrazones with iodoarene derivatives containing a nucleophilic group has been developed, which provides facile access to 2H-chromenes and 2H-quinolines, respectively. Additionally, the double Pd-carbene migratory insertion/nucleophilic substitution processes for the synthesis of a ternary heterocyclic skeleton were possible in the developed catalytic system.
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