斑马鱼作为多发性硬化症的模型

IF 3.9 3区 工程技术 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomedicines Pub Date : 2024-10-16 DOI:10.3390/biomedicines12102354
Briana Maktabi, Abigail Collins, Raihaanah Safee, Jada Bouyer, Alexander S Wisner, Frederick E Williams, Isaac T Schiefer
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引用次数: 0

摘要

背景:斑马鱼因其独特的优势已成为神经科学研究的重要模式生物。斑马鱼在遗传学、解剖学和生理学方面与人类相似,而且发育迅速,胚胎透明,因此是研究神经生物学各个方面的绝佳工具。特别是在生物医学研究中,包括在研究多发性硬化症等神经系统疾病方面,它们已成为一种有价值的多功能模式生物。多发性硬化症是一种慢性自身免疫性疾病,已知会导致保护大脑和脊髓神经的髓鞘受损。目的:本综述强调了继续在体外和体内模型中进行研究的重要性,以促进我们对多发性硬化症的了解并开发有效的治疗方法,最终改善这种使人衰弱的疾病患者的生活质量。结论最近的研究表明,斑马鱼是研究脱髓鞘和再髓鞘化过程的重要模式生物,为多发性硬化症的病理和潜在疗法提供了新的见解。
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Zebrafish as a Model for Multiple Sclerosis.

Background: Zebrafish have become a key model organism in neuroscience research because of their unique advantages. Their genetic, anatomical, and physiological similarities to humans, coupled with their rapid development and transparent embryos, make them an excellent tool for investigating various aspects of neurobiology. They have specifically emerged as a valuable and versatile model organism in biomedical research, including the study of neurological disorders such as multiple sclerosis. Multiple sclerosis is a chronic autoimmune disease known to cause damage to the myelin sheath that protects the nerves in the brain and spinal cord. Objective: This review emphasizes the importance of continued research in both in vitro and in vivo models to advance our understanding of MS and develop effective treatments, ultimately improving the quality of life for those affected by this debilitating disease. Conclusions: Recent studies show the significance of zebrafish as a model organism for investigating demyelination and remyelination processes, providing new insights into MS pathology and potential therapies.

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来源期刊
Biomedicines
Biomedicines Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.20
自引率
8.50%
发文量
2823
审稿时长
8 weeks
期刊介绍: Biomedicines (ISSN 2227-9059; CODEN: BIOMID) is an international, scientific, open access journal on biomedicines published quarterly online by MDPI.
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