洞察病毒 G 蛋白偶联受体的结构特性及其在病毒感染中的作用:IUPHAR Review 41.

IF 6.8 2区 医学 Q1 PHARMACOLOGY & PHARMACY British Journal of Pharmacology Pub Date : 2024-10-23 DOI:10.1111/bph.17379
Naotaka Tsutsumi, Dagmar Fæster Kildedal, Olivia Kramer Hansen, Qianqian Kong, Dominique Schols, Tom Van Loy, Mette Marie Rosenkilde
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引用次数: 0

摘要

G 蛋白偶联受体(GPCR)在细胞信号传导和药物靶向中起着关键作用。疱疹病毒编码 GPCRs(vGPCRs)来操纵细胞信号,从而调节病毒生命周期的各个方面,如病毒传播和免疫逃避。vGPCRs 模仿宿主趋化因子受体,通常具有更广泛的信号传导和高组成活性。本综述重点介绍 vGPCR 结构知识的最新进展,重点是分子作用机制和配体结合。本文将人类巨细胞病毒(HCMV)中的 US27 和 US28 的结构与其最接近的人类同源物 CX3CR1 进行了比较。与 US27 和 US28 相比,同源三聚体 UL78 结构(HCMV)更接近趋化因子受体。开放阅读框 74(ORF74;卡波西肉瘤相关疱疹病毒)与 CXCR 进行了比较,而 BILF1(Epstein-Barr 病毒)被认为是一种假定的脂质受体。此外,还综述了 vGPCR 在潜伏和溶解复制、再活化、传播和免疫逃避中的作用,以及它们作为病毒感染和病毒相关疾病药物靶点的潜力。
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Insight into structural properties of viral G protein-coupled receptors and their role in the viral infection: IUPHAR Review 41.

G protein-coupled receptors (GPCRs) are pivotal in cellular signalling and drug targeting. Herpesviruses encode GPCRs (vGPCRs) to manipulate cellular signalling, thereby regulating various aspects of the virus life cycle, such as viral spreading and immune evasion. vGPCRs mimic host chemokine receptors, often with broader signalling and high constitutive activity. This review focuses on the recent advancements in structural knowledge about vGPCRs, with an emphasis on molecular mechanisms of action and ligand binding. The structures of US27 and US28 from human cytomegalovirus (HCMV) are compared to their closest human homologue, CX3CR1. Contrasting US27 and US28, the homotrimeric UL78 structure (HCMV) reveals more distance to chemokine receptors. Open reading frame 74 (ORF74; Kaposi's sarcoma-associated herpesvirus) is compared to CXCRs, whereas BILF1 (Epstein-Barr virus) is discussed as a putative lipid receptor. Furthermore, the roles of vGPCRs in latency and lytic replication, reactivation, dissemination and immune evasion are reviewed, together with their potential as drug targets for virus infections and virus-related diseases.

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来源期刊
CiteScore
15.40
自引率
12.30%
发文量
270
审稿时长
2.0 months
期刊介绍: The British Journal of Pharmacology (BJP) is a biomedical science journal offering comprehensive international coverage of experimental and translational pharmacology. It publishes original research, authoritative reviews, mini reviews, systematic reviews, meta-analyses, databases, letters to the Editor, and commentaries. Review articles, databases, systematic reviews, and meta-analyses are typically commissioned, but unsolicited contributions are also considered, either as standalone papers or part of themed issues. In addition to basic science research, BJP features translational pharmacology research, including proof-of-concept and early mechanistic studies in humans. While it generally does not publish first-in-man phase I studies or phase IIb, III, or IV studies, exceptions may be made under certain circumstances, particularly if results are combined with preclinical studies.
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