重症巨细胞病毒先天性感染与神经系统损害--墨西哥病例系列研究:严重巨细胞病毒感染和神经系统功能损害。

IF 1 Q4 INFECTIOUS DISEASES Case Reports in Infectious Diseases Pub Date : 2024-10-17 eCollection Date: 2024-01-01 DOI:10.1155/2024/7510447
Saúl Flores-Medina, Ricardo Figueroa Damian, Gabriela Arreola-Ramírez, Noemi Plazola-Camacho, Graciela Villeda-Gabriel, Sara A Ochoa, Ariadnna Cruz-Córdova, Juan Xicohtencatl-Cortes, José Arellano-Galindo
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引用次数: 0

摘要

本报告描述了四例严重的先天性巨细胞病毒(CMV)感染病例。所有病例均在产后通过脑脊液(3/4)或血液 PCR(1/4)和胎盘组织化学检查(4/4)确诊。所有婴儿均为早产儿。孕产妇的重要因素是怀孕年龄较小和来自低收入社会阶层。先天性巨细胞病毒感染患者的主要临床表现为脑积水和持续性血小板减少。患儿的临床状况在病程中没有改善,导致了与极度早产有关的并发症。其中两名患儿死亡,一名患儿有严重的脑畸形,随访时出现神经系统损害、癫痫发作、运动障碍和严重的认知发育迟缓。即使在墨西哥等血清阳性率较高的国家,也必须对孕妇进行可能感染巨细胞病毒的产前筛查,以制定产前干预措施,降低胎儿受损的风险。
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Severe Cytomegalovirus Congenital Infection With Neurological Compromise a Case Series Study in Mexico: Severe CMV and Neurological Compromise.

Four cases of serious congenital cytomegalovirus (CMV) infections are described in this report. All cases were diagnosed postnatally using cerebrospinal fluid (3/4) or blood PCR (1/4) and histochemical study of the placenta (4/4). All infants were born prematurely. Maternal factors identified as significant were younger age at pregnancy and those from low-income social strata. The major clinical findings among patients with congenital CMV infection were hydrocephalus and persistent thrombocytopenia. The children's clinical condition did not improve over the course of the disease, leading to complications associated with extreme prematurity. Two of the children died, one of whom had severe brain malformations and showed neurological compromise at follow-up, seizures, motor impairment, and severe cognitive delay. It is essential to perform antenatal screening for possible CMV infection among pregnant women, even in countries with high population seropositivity, such as Mexico, to establish prenatal interventions to reduce the risk of fetal damage.

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