Guan-Ke Liu , Bing-Yang Zhang , Zheng Niu , Jia-Qi Chen , Chun-Yu Fan , Xin-Yue Deng , Fan-Qing Ye , Shi-Jie Cao , Ning Kang , Tie Yao , Feng Qiu
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Triterpenoids from the rhizomes and roots of Gentiana scabra Bge. and their cytotoxic activities
Phytochemical investigation on the rhizomes and roots of Gentiana scabra (Gentianaceae) led to the isolation of five new triterpenoids (1–5), together with seven known ones (6–12). The structures and absolute configurations of the new compounds were elucidated by spectroscopic data interpretation, ECD calculation and X-ray crystallographic analysis. Noticeably, compound 4 was an uncommon 3,4-seco-pentacyclic triterpenoid in natural products. The in vitro cytotoxic activities of all isolates against human cancer cell lines (HepG2, Hep3B, HCT116, and U87) were measured using MTT assay. Among them, compounds 2–9, 11, and 12 exhibited anti-proliferative effects against these tumor cell lines.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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