Yingbo Yang , Qian Zhang , Jia Wang , Haijun Hu , Meng Wang , Zhengtao Wang , Zhuzhen Han , Ying Xiao , Li Yang
{"title":"毛蕊花的生物活性成分及其α-葡萄糖苷酶抑制剂和 PPAR-γ 激动剂活性。","authors":"Yingbo Yang , Qian Zhang , Jia Wang , Haijun Hu , Meng Wang , Zhengtao Wang , Zhuzhen Han , Ying Xiao , Li Yang","doi":"10.1016/j.fitote.2024.106266","DOIUrl":null,"url":null,"abstract":"<div><div>Three new neoclerodane diterpenoids (<strong>1–3</strong>), two new steroids (<strong>4–5</strong>), one new monoterpene (<strong>6</strong>), one new derivative of benzaldehyde (<strong>7</strong>) and one new iridoid glycoside (<strong>8</strong>), along with 19 known phenolic compounds, were isolated from <em>Clerodendrum trichotomum</em>. Their structures were established by a combination of detailed spectroscopic analyses (1D and 2D NMR) and high resolution electrospray ionization mass spectroscopy (HRESIMS). The isolated compounds were screened on <em>α</em>-glucosidase inhibitory and the peroxisome proliferator-activated receptor gamma (PPAR-<em>γ</em>) agonist activities, and the results showed that three phenylethanoid glycosides, verbascoside (<strong>9</strong>), leucosceptoside a (<strong>10</strong>), and isoacteoside (<strong>13</strong>), and two flavonoids, apigenin (<strong>22</strong>) and luteolin (<strong>26</strong>) showed potent inhibitory effects against α-glucosidase, with IC<sub>50</sub> values in the range from 15 to 700 μM. In addition, four flavonoids apigenin 7<em>-O-β</em>-D-glucuronide (<strong>19</strong>), apigenin (<strong>22</strong>), luteolin (<strong>26</strong>), and quercetin (<strong>27</strong>) exhibited significant PPAR-<em>γ</em> agonistic activities with EC<sub>50</sub> values in the range 2.3–24.9 μM.</div></div>","PeriodicalId":12147,"journal":{"name":"Fitoterapia","volume":"179 ","pages":"Article 106266"},"PeriodicalIF":2.5000,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Bioactive constituents from Clerodendrum trichotomum and their α-glucosidase inhibitory and PPAR-γ agonist activities\",\"authors\":\"Yingbo Yang , Qian Zhang , Jia Wang , Haijun Hu , Meng Wang , Zhengtao Wang , Zhuzhen Han , Ying Xiao , Li Yang\",\"doi\":\"10.1016/j.fitote.2024.106266\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Three new neoclerodane diterpenoids (<strong>1–3</strong>), two new steroids (<strong>4–5</strong>), one new monoterpene (<strong>6</strong>), one new derivative of benzaldehyde (<strong>7</strong>) and one new iridoid glycoside (<strong>8</strong>), along with 19 known phenolic compounds, were isolated from <em>Clerodendrum trichotomum</em>. Their structures were established by a combination of detailed spectroscopic analyses (1D and 2D NMR) and high resolution electrospray ionization mass spectroscopy (HRESIMS). The isolated compounds were screened on <em>α</em>-glucosidase inhibitory and the peroxisome proliferator-activated receptor gamma (PPAR-<em>γ</em>) agonist activities, and the results showed that three phenylethanoid glycosides, verbascoside (<strong>9</strong>), leucosceptoside a (<strong>10</strong>), and isoacteoside (<strong>13</strong>), and two flavonoids, apigenin (<strong>22</strong>) and luteolin (<strong>26</strong>) showed potent inhibitory effects against α-glucosidase, with IC<sub>50</sub> values in the range from 15 to 700 μM. In addition, four flavonoids apigenin 7<em>-O-β</em>-D-glucuronide (<strong>19</strong>), apigenin (<strong>22</strong>), luteolin (<strong>26</strong>), and quercetin (<strong>27</strong>) exhibited significant PPAR-<em>γ</em> agonistic activities with EC<sub>50</sub> values in the range 2.3–24.9 μM.</div></div>\",\"PeriodicalId\":12147,\"journal\":{\"name\":\"Fitoterapia\",\"volume\":\"179 \",\"pages\":\"Article 106266\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-10-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Fitoterapia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0367326X24004490\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Fitoterapia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0367326X24004490","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Bioactive constituents from Clerodendrum trichotomum and their α-glucosidase inhibitory and PPAR-γ agonist activities
Three new neoclerodane diterpenoids (1–3), two new steroids (4–5), one new monoterpene (6), one new derivative of benzaldehyde (7) and one new iridoid glycoside (8), along with 19 known phenolic compounds, were isolated from Clerodendrum trichotomum. Their structures were established by a combination of detailed spectroscopic analyses (1D and 2D NMR) and high resolution electrospray ionization mass spectroscopy (HRESIMS). The isolated compounds were screened on α-glucosidase inhibitory and the peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist activities, and the results showed that three phenylethanoid glycosides, verbascoside (9), leucosceptoside a (10), and isoacteoside (13), and two flavonoids, apigenin (22) and luteolin (26) showed potent inhibitory effects against α-glucosidase, with IC50 values in the range from 15 to 700 μM. In addition, four flavonoids apigenin 7-O-β-D-glucuronide (19), apigenin (22), luteolin (26), and quercetin (27) exhibited significant PPAR-γ agonistic activities with EC50 values in the range 2.3–24.9 μM.
期刊介绍：
Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas:
1. Characterization of active ingredients of medicinal plants
2. Development of standardization method for bioactive plant extracts and natural products
3. Identification of bioactivity in plant extracts
4. Identification of targets and mechanism of activity of plant extracts
5. Production and genomic characterization of medicinal plants biomass
6. Chemistry and biochemistry of bioactive natural products of plant origin
7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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